{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:49:42Z","timestamp":1774381782593,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T00:00:00Z","timestamp":1169424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the association of second\u2010trimester maternal serum alpha\u2010fetoprotein (MSAFP) and free beta human chorionic gonadotrophin (MS\u03b2\u2010hCG) levels to placental abruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010seven women with placental abruption and 108 control women without placental abruption were tested for second\u2010trimester MSAFP and MS\u03b2\u2010hCG levels as a part of a trisomy 21 screening program. Discriminatory cutoff levels for MSAFP were sought to predict placental abruption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median of the MSAFP multiples of median (MoM) (1.21) was significantly higher in the abruption group than in the control group (1.07) (<jats:italic>p<\/jats:italic> = 0.004). In multivariate analysis, elevated MSAFP remained an independent risk factor for placental abruption when adjusting for other risk factors (parity \u2265 3, smoking, previous placental abruption, preeclampsia, bleeding in II or III trimester, and placenta previa). MSAFP \u2265 1.5 MoM had a sensitivity of 29% and a false\u2010positive rate of 10%. The levels of the MS\u03b2\u2010hCG MoM did not differ between the cases and the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although second\u2010trimester MSAFP levels are higher in women with subsequent placental abruption, the clinical usefulness of this test is limited due to low sensitivity and high false\u2010positive rate. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.1654","type":"journal-article","created":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T11:00:47Z","timestamp":1169463647000},"page":"240-243","source":"Crossref","is-referenced-by-count":26,"title":["Elevated maternal second\u2010trimester serum alpha\u2010fetoprotein as a risk factor for placental abruption"],"prefix":"10.1002","volume":"27","author":[{"given":"Minna","family":"Tikkanen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esa","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Nuutila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma","family":"Paavonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olavi","family":"Ylikorkala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilho","family":"Hiilesmaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00408-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.087"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00769-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000172419.37410.eb"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(97)00199-1"},{"key":"e_1_2_1_7_1","first-page":"689","volume-title":"Medicine of the Fetus and Mother","author":"Haddow JE","year":"1999"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.114864"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199011000-00001"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.55418\/1881041891","volume-title":"Placental Pathology. 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