{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:26:54Z","timestamp":1757701614429},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,5]],"date-time":"2007-02-05T00:00:00Z","timestamp":1170633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this retrospective study was to determine whether objective assessment of cardiac shifting on two\u2010dimensional ultrasonography can predict postnatal outcome in fetuses with isolated left\u2010sided congenital diaphragmatic hernia (CDH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Still images at the level of the four\u2010chamber view were obtained in 23 fetuses with left\u2010sided CDH. A group of 12 fetuses (3 non\u2010survivors and 9 survivors) were examined at two periods, between 20 and 30 weeks and between 31 and 40 weeks. A further 11 fetuses (2 non\u2010survivors and 9 survivors) were examined between 31 and 40 weeks. Fetal heart axis and position were determined manually and associated with postnatal outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cardiac axis remained constant in the 9 survivors (15.5 \u00b1 3.2 <jats:italic>versus<\/jats:italic> 17.2 \u00b1 3.3, <jats:italic>p<\/jats:italic> = 0.71) and 3 non\u2010survivors (19.0 \u00b1 11.5 <jats:italic>versus<\/jats:italic> 18.5 \u00b1 11.8, <jats:italic>p<\/jats:italic> = 0.97). There was no statistical difference between the 9 survivors and 3 non\u2010survivors at the two periods. Cardiac displacement remained constant in the 9 survivors (0.2 \u00b1 0.02 <jats:italic>versus<\/jats:italic> 0.2 \u00b1 0.02, <jats:italic>p<\/jats:italic> = 0.32) but increased significantly in the 3 non\u2010survivors (0.2 \u00b1 0.04 <jats:italic>versus<\/jats:italic> 0.4 \u00b1 0.02, <jats:italic>p<\/jats:italic> = 0.015). The difference between survivors and non\u2010survivors was statistically significant between the18 survivors and 5 non\u2010survivors examined between 31 and 40 weeks of gestation (0.2 \u00b1 0.02 <jats:italic>versus<\/jats:italic> 0.4 \u00b1 0.02, <jats:italic>p<\/jats:italic> = 0.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study does not support the hypothesis that objective assessment of mediastinal shift in fetuses with left\u2010sided CDH has a role in predicting postnatal outcome before fetal viability, which is when it would be more useful for counseling patients regarding whether to continue with the pregnancy or to opt for termination. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.1669","type":"journal-article","created":{"date-parts":[[2007,2,5]],"date-time":"2007-02-05T11:29:13Z","timestamp":1170674953000},"page":"322-326","source":"Crossref","is-referenced-by-count":8,"title":["Isolated left\u2010sided congenital diaphragmatic hernia: cardiac axis and displacement before fetal viability has no role in predicting postnatal outcome"],"prefix":"10.1002","volume":"27","author":[{"given":"Karim D.","family":"Kalache","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Mkhitaryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bamberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles Christoph","family":"Roehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Wauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Mau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Bollmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(85)80219-0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199811)18:11<1138::AID-PD416>3.0.CO;2-A"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1993.03020093.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30210-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089046"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91351-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.127130"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00327-3"},{"key":"e_1_2_1_10_1","first-page":"255","article-title":"Normal fetal heart axis and position","volume":"70","author":"Comstock CH","year":"1987","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb03286.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870140910"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/jpsu.2003.50194"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035005"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2688"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1001\/jama.1994.03520010039019","article-title":"Cardiac function in fetuses with congenital diaphragmatic hernia","volume":"272","author":"Karamanoukian HL","year":"1994","journal-title":"JAMA"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92720-M"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.654"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90338-3"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003830100625"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91817-T"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(84)80105-0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.122413"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003830050429"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"10062","DOI":"10.1007\/s001340050457","article-title":"Congenital diaphragmatic hernia: antenatal prognostic factors. 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