{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:56:47Z","timestamp":1791766607215,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,6,4]],"date-time":"2007-06-04T00:00:00Z","timestamp":1180915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the influence of numerical chromosomal abnormalities on preimplantation embryo development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study includes 6936 embryos from 1245 women undergoing preimplantation genetic diagnosis (PGD). Indications for aneuploidy screening were: recurrent miscarriages, implantation failure, severe male factor, advanced maternal age, and mixed causes. Embryo biopsy was performed on day 3, and embryos were co\u2010cultured until day 5, when embryo transfer was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the aneuploidy screening regimen, normal euploid embryos showed significantly higher blastocyst rates (68.2%) compared to chromosomally abnormal (42.8%, p &lt; 0.0001) and mosaic (53.7%, p &lt; 0.0001) embryos. Among aneuploid embryos for autosomes, higher blastocyst rates were observed in trisomies than monosomies, although only statistically significant in patients over 36 years of age (50.8 vs 38.9%; p &lt; 0.0001). In contrast, in embryos with sex chromosomes aneuploidy, similar blastocyst rates were observed between trisomies and monosomy X.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Embryos with certain types of chromosomal abnormalities were negatively selected during preimplantation embryo development. Despite this selection, a remarkable percentage of chromosomally abnormal embryos can develop normally to blastocyst stage with high probability of implantation and pregnancy. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.1773","type":"journal-article","created":{"date-parts":[[2007,6,4]],"date-time":"2007-06-04T09:19:37Z","timestamp":1180948777000},"page":"748-756","source":"Crossref","is-referenced-by-count":108,"title":["Impact of chromosomal abnormalities on preimplantation embryo development"],"prefix":"10.1002","volume":"27","author":[{"given":"Carmen","family":"Rubio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"Mercader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Mateu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Buend\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugce","family":"Pehlivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamara","family":"Viloria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma Jos\u00e9","family":"De los Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Sim\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Remoh\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pellicer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00092-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD9960235"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei291"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60984-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.03.031"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420120103"},{"key":"e_1_2_1_8_1","first-page":"656","article-title":"Cytogenetic analysis of 750 spontaneous abortions with the direct preparation method of chorionic villi and its implications for studying genetic causes of pregnancy wastage","volume":"47","author":"Eiben B","year":"1990","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.11.3151"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg458"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00596-X"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg092"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/35066065"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2660(08)60332-6"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod54.1.53"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.04.068"},{"key":"e_1_2_1_17_1","first-page":"183","article-title":"Chromosome constitution of 500 infants dying during the perinatal period","volume":"23","author":"Mach\u00edn GA","year":"1974","journal-title":"Humangenetik"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.8.1781"},{"key":"e_1_2_1_19_1","first-page":"277","article-title":"Nuclearcytoplasmic interactions in the mouse embryo","volume":"97","author":"McGrath J","year":"1986","journal-title":"J Embryol Exp Morphol"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)01178-6"},{"key":"e_1_2_1_21_1","article-title":"Development of abnormal embryos in sequential culture versus co\u2010culture systems","author":"Mercader A","year":"2003","journal-title":"Reprod Biomed Online"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60866-8"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60501-9"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1220687"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF00281456","article-title":"Chromosome examination of newborn children. 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