{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T05:55:14Z","timestamp":1717998914556},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,6,25]],"date-time":"2007-06-25T00:00:00Z","timestamp":1182729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To validate Down syndrome screening protocols that include hyperglycosylated\u2010hCG (h\u2010hCG) measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Measuring h\u2010hCG in 21 641 fresh first\u2010 and second\u2010trimester maternal serum samples, but not for clinical interpretation. Nuchal translucency (NT) and pregnancy associated plasma protein\u2010A (PAPP\u2010A) measurements were available in the first trimester; alpha\u2010fetoprotein (AFP), unconjugated estriol (uE3), and human chorionic gonadotropin (hCG) measurements in the second trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 23 first\u2010 and 26 second\u2010trimester Down syndrome pregnancies identified, 52 and 65% of h\u2010hCG measurements were above the 95th centile, respectively. At a 3% false positive rate, maternal age, NT, PAPP\u2010A and h\u2010hCG detected 78% of cases (95% CI, 56\u201393%). Other combinations were consistent with previous modeling utilizing stored samples. A literature summary indicates h\u2010hCG is as strong a marker as free\u2010\u03b2 between 10 and 13 weeks' gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Down syndrome screening performance of h\u2010hCG using fresh samples meets published expectations based on stored samples. h\u2010hCG could replace free \u03b2 measurements, at gestational ages as early as 10 weeks. 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