{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T23:40:39Z","timestamp":1700005239776},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T00:00:00Z","timestamp":1204502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>First\u2010trimester maternal serum screening for Down syndrome (DS) can be improved by the use of additional serum markers. We examined whether progesterone (P), synthesized by placenta, might be a first\u2010trimester maternal serum marker for fetal DS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>P was quantified in first\u2010trimester maternal serum from 42 DS, six trisomy 18 and two trisomy 13 pregnancies and 115 controls. Log\u2010regression of P versus gestational age in days was used to convert P concentrations into multiples of the median (MoM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The P concentrations in controls increased with gestational age (<jats:italic>p<\/jats:italic> = 9.5 \u00d7 10<jats:sup>\u22127<\/jats:sup>). The log10MoM P distribution in DS pregnancies was not significantly different from that in controls. However, from day 58\u201367, the log10MoM P was elevated in DS pregnancies (<jats:italic>n<\/jats:italic> = 10) with a mean (SD) of 0.1040 (0.0956), compared to a mean (SD) of \u2212 0.0109 (0.1661) in controls (<jats:italic>n<\/jats:italic> = 24) (<jats:italic>p<\/jats:italic> = 0.05). Five out of six trisomy 18 and both trisomy 13 pregnancies had a P MoM &lt; 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>P is not a useful marker for DS in first trimester, except perhaps in a narrow gestational age window from day 58 to 67. P is a trisomy 18\/13 marker. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.1843","type":"journal-article","created":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T13:47:16Z","timestamp":1204552036000},"page":"319-322","source":"Crossref","is-referenced-by-count":4,"title":["First\u2010trimester maternal serum progesterone in aneuploid pregnancies"],"prefix":"10.1002","volume":"28","author":[{"given":"Michael","family":"Christiansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina Lindvig","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Severin 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