{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:44:51Z","timestamp":1761155091208},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,10,25]],"date-time":"2007-10-25T00:00:00Z","timestamp":1193270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2007,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>High level of soluble endoglin (sEng), a potent antiangiogenic factor, predicts pre\u2010eclampsia. We compared the serum levels of sEng in early second trimester in women with and without subsequent placental abruption. Proangiogenic placental growth factor (PlGF) and antiangiogenic soluble fms\u2010like tyrosine kinase 1 (sFlt\u20101) were also studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum samples of 42 women with placental abruption and 50 control women, collected at 15 to 16 gestational weeks were analyzed for sEng, sFlt\u20101 and PlGF by immunoassays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels of sEng showed no difference between the cases and controls, but parous or smoking women with abruption had lower levels of sEng. Similarly, sFlt\u20101, PlGF, or sFlt\u20101\/PlGF ratio showed no difference between the cases and the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggest that sEng, PlGF and sFlt\u20101 levels in early second trimester fail to predict placental abruption. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.1869","type":"journal-article","created":{"date-parts":[[2007,10,25]],"date-time":"2007-10-25T18:16:09Z","timestamp":1193336169000},"page":"1143-1146","source":"Crossref","is-referenced-by-count":12,"title":["Failure of second\u2010trimester measurement of soluble endoglin and other angiogenic factors to predict placental abruption"],"prefix":"10.1002","volume":"27","author":[{"given":"Minna","family":"Tikkanen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf\u2010H\u00e5kan","family":"Stenman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Nuutila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma","family":"Paavonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilho","family":"Hiilesmaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olavi","family":"Ylikorkala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,10,25]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00408-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13848.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.55418\/1881041891-04","volume-title":"Placental Pathology. 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