{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T05:19:31Z","timestamp":1774070371846,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,2,27]],"date-time":"2008-02-27T00:00:00Z","timestamp":1204070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007037","name":"Danish Ministry of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007037","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish the relationship between the first\u2010trimester screening markers [pregnancy\u2010associated plasma protein A (PAPP\u2010A), free human chorionic gonadotrophin\u2010\u03b2 (\u03b2\u2010hCG), nuchal translucency (NT)], the Down syndrome (DS) risk estimate, and the adverse outcomes such as low birth weight, small for gestational age (SGA) and pre\u2010term delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study including 1734 non\u2010selected singleton pregnancies consecutively enrolled into the programme of first\u2010trimester combined screening for DS in a 12\u2010month period at a single centre. Data from the Prenatal Patient Registry in ASTRAIA were combined with the Danish National Newborn Screening Registry and Danish Birth Registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant relation between low PAPP\u2010A MoM, low \u03b2\u2010hCG MoM, increased risk estimate for DS and low birth weight and SGA. Low PAPP\u2010A MoM and increased NT showed a significant relation to pre\u2010term and spontaneous pre\u2010term delivery. Low PAPP\u2010A MoM showed a significant relation to early pre\u2010term delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>First\u2010trimester screening markers exhibited a significant relation to low birth weight, SGA and to some extent, to pre\u2010term and early pre\u2010term delivery. The screening performance of individual markers was poor. 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