{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:45:15Z","timestamp":1792723515068,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T00:00:00Z","timestamp":1204502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether pregnancies with small for gestational age (SGA) neonates, defined as customized birth weight below the 10th centile, are associated with altered levels of metastin in maternal plasma in the first trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Maternal blood was obtained between 8 and 14 weeks of pregnancy. Levels of metastin were measured in pregnancies with (<jats:italic>n<\/jats:italic> = 31) or without SGA\u2010neonates (<jats:italic>n<\/jats:italic> = 31), matched for gestational age at venipuncture. Measurement of \u03b2\u2010hCG was included to study the influence of gestational age and placental volume on plasma levels of the measured markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Metastin was significantly lower in SGA\u2010pregnancies compared to an equal number of matched uneventful pregnancies (metastin: 1376 \u00b1 1317 pmol\/L vs 2035 \u00b1 1260 pmol\/L, <jats:italic>p<\/jats:italic> = 0.035; mean \u00b1 standard deviation). \u03b2\u2010hCG levels were not different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Metastin is significantly lower in maternal plasma in the first trimester, in pregnancies with SGA\u2010neonates. It might therefore be used in combination with other markers for risk estimation of growth impairment in the first trimester. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.1969","type":"journal-article","created":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T13:47:23Z","timestamp":1204552043000},"page":"299-303","source":"Crossref","is-referenced-by-count":51,"title":["Decreased plasma levels of metastin in early pregnancy are associated with small for gestational age neonates"],"prefix":"10.1002","volume":"28","author":[{"given":"Eva M. L.","family":"Smets","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen L.","family":"Deurloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attie T. J. I.","family":"Go","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M. 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