{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:04:04Z","timestamp":1761717844181},"reference-count":18,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2002,1,8]],"date-time":"2002-01-08T00:00:00Z","timestamp":1010448000000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A prospective study was performed on 2119 pregnancies that underwent genetic amniocentesis. Indications for amniocentesis were either maternal age (\u2a7e35) or triple\u2010test results (risk\u2a7e1\/380).<\/jats:p><jats:p>The study covered a 36\u2010month period and assessed the prevalence of minor ultrasound markers both in fetuses with Down syndrome and normal control fetuses at 15\u201319 week' gestation.<\/jats:p><jats:p>Only fetuses with normal karyotype or trisomy 21 were considered.<\/jats:p><jats:p>Six minor sonographic markers were considered: nuchal thickness, pyelectasia, femur observed\/expected and humerus observed\/expected ratios, bowel echogenicity, and choroid plexus cysts. One or more ultrasound soft markers were present in 23 out of 33 fetuses with Down syndrome (70%) and in 572 out of 2069 normal fetuses (28%). Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/pd.197","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T16:30:43Z","timestamp":1030293043000},"page":"1163-1166","source":"Crossref","is-referenced-by-count":15,"title":["Minor sonographic signs of trisomy 21 at 15\u201320 weeks' gestation in fetuses born without malformations: a prospective study"],"prefix":"10.1002","volume":"21","author":[{"given":"E.","family":"Viora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Errante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bastonero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sciarrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Campogrande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,1,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91334-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07020147.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00141.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10050321.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12060391.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12010006.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(94)00327-A"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7235.606"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00292-9"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.2307\/2288562"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91322-X"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1998.12010008.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200001)20:1<17::AID-PD744>3.0.CO;2-Y"},{"key":"e_1_2_1_15_1","volume-title":"Ultrasound Markers for Fetal Chromosomal Defects","author":"Snijders RJM","year":"1996"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1999.18.7.469"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90008-X"},{"issue":"2","key":"e_1_2_1_18_1","first-page":"79","article-title":"Minor sonographic markers of fetal chromosomal anomalies: a review","volume":"11","author":"Viora E","year":"1999","journal-title":"Italian J Obstet Gynecol"},{"key":"e_1_2_1_19_1","unstructured":"YagelS AntebyEY Hochner\u2010CelnikierD ArielI ChaapT Ben NeriahZ.1998.The role of mid trimester targeted fetal organ screening combined with the \u2018triple test\u2019 and maternal age in the diagnosis."}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.197","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T14:22:37Z","timestamp":1700317357000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":18,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1002\/pd.197"],"URL":"https:\/\/doi.org\/10.1002\/pd.197","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}