{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:43:33Z","timestamp":1761155013456},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":8905,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1981,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal morphology of Meckel's syndrome was studied in five fetuses of different gestational age, that had been aborted because ultrasonography and elevated amniotic AFP\u2010levels indicated neural tube defect. Histologically, the enlarged polycystic kidneys were completely alike with respect to the type of involvement and differed only in the severity of changes. They could be identified as type III cystic kidneys according to the classification of Potter. Proliferation of hepatic bile ducts and slight cystic dilatation of pancreatic ducts is already evident in the youngest fetus. Additional cyst formation in the epididymis was found in one of the cases. Occipital encephalocele, located within an apical occipital bone defect was always associated with a second mostly occult encephalocele protruding through a separate defect of the basal occipital squame and of the first and second vertebral arch. It is assumed that double encephalocele represents a constant finding in Meckel's syndrome, indicating a specific pattern within the disturbance of neural tube closure.<\/jats:p>","DOI":"10.1002\/pd.1970010302","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:02:49Z","timestamp":1172962969000},"page":"161-171","source":"Crossref","is-referenced-by-count":27,"title":["Prenatal morphology in meckel's syndrome (with special reference to polycystic kidneys and double encephalocele)"],"prefix":"10.1002","volume":"1","author":[{"given":"Helga","family":"Rehder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Labb\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00402165"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(77)90659-7"},{"key":"e_1_2_1_4_1","first-page":"541","volume-title":"Pediatric Kidney Disease II","author":"Bernstein J.","year":"1978"},{"key":"e_1_2_1_5_1","series-title":"Birth Defects: Orig. Article Series Vol. X, No. 4","first-page":"35","volume-title":"The renal lesions in syndromes of multiple congenital malformations. Cerebrohepatorenal syndrome; Jeune asphyxiating thoracic dystrophy; tuberous sclerosis; Meckel syndrome","author":"Bernstein J.","year":"1974"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1136\/jmg.8.3.257","article-title":"Polycystic disease in kidneys and liver presenting in childhood","volume":"8","author":"Blyth H.","year":"1971","journal-title":"J. Med. Genet."},{"key":"e_1_2_1_7_1","first-page":"181","volume-title":"Clinical Pediatric Urology","author":"Campbell M. F.","year":"1951"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1977.tb01314.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.15.3.242"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.8.3.285"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1979.tb00980.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091890407"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690449"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1542\/peds.48.2.237","article-title":"Genetics of the Meckel syndrome (Dysencephalia splanchnocystica)","volume":"48","author":"Hsia Y. E.","year":"1971","journal-title":"Pediatrics"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278842"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","unstructured":"Leucht W. Heyes H. Goessens L. Rehder H. Jonatha W.1981 Das Meckel\u2010Syndrom\u2014Pr\u00e4natale Diagnostik und genetische Beratung Z. Geburtshilfe Frauenheilk. in press.","DOI":"10.1055\/s-2008-1036986"},{"key":"e_1_2_1_17_1","first-page":"97","article-title":"Encephalocele, polycystic kidneys, and polydactyly as an autosomal recessive trait simulating certain other disorders: The Meckel syndrome","volume":"14","author":"Mecke S.","year":"1971","journal-title":"Ann. G\u00e9n\u00e9t. (Paris)"},{"key":"e_1_2_1_18_1","first-page":"99","article-title":"Beschreibung zweier durch sehr \u00e4hnliche Bildungsabweichungen entstellter Geschwister","volume":"7","author":"Meckel J. F.","year":"1822","journal-title":"Dtsch. Arch. Physiol."},{"key":"e_1_2_1_19_1","first-page":"1069","article-title":"A propos de trois nouveaux cas dans une m\u011bme fratrie du syndrome de Meckel ou dysenc\u00e9phalie splanchnokystique de Gruber","volume":"29","author":"Naffah J.","year":"1972","journal-title":"Arch. P\u00e9diatr."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1979.tb02021.x"},{"key":"e_1_2_1_21_1","series-title":"Birth Defects: Original Article Series","first-page":"167","volume-title":"The Meckel syndrome (Dysencephalia splanchnocystica, the Gruber syndrome)","author":"Opitz J. M.","year":"1969"},{"key":"e_1_2_1_22_1","volume-title":"Normal and Abnormal Development of the Kidney","author":"Potter E. L.","year":"1972"},{"key":"e_1_2_1_23_1","volume-title":"Pathology of the Fetus and the Infant","author":"Potter E. L.","year":"1976"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","unstructured":"Rehder H.1981 The pathology of trisomy 21 with particular reference to persistent common atrio\u2010ventricular canal of the heart.Hum. Genet. Suppl. 2 57\u201373.","DOI":"10.1007\/978-3-642-68006-9_5"},{"key":"e_1_2_1_25_1","unstructured":"Schmidt W. Michniger G. Schroeder T. M. Kubli F.1981 Prenatal diagnosis of Potter syndrome' and other kidney diseases Prenatal Diagnosis in press."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.12.1.109"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1542\/peds.39.6.931","article-title":"Polycystic kidneys, internal hydrocephalus and polydactylism in newborn siblings","volume":"39","author":"Simopoulos A. P.","year":"1967","journal-title":"Pediatrics"},{"key":"e_1_2_1_28_1","volume-title":"Recognizable Patterns of Human Malformations","author":"Smith D. 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