{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:06Z","timestamp":1760188866574},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":8631,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1982,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The concentration of 17OH\u2010progesterone was measured in second trimester amniotic fluid samples from 12 mothers who previously had had an infant with congenital adrenal hyper\u2010plasia due to 21\u2010hydroxylase deficiency. In 4 affected pregnancies, the concentrations were more than 2 S.D. higher than those determined in 44 samples from normal pregnancies (mean \u00b1 S.D., 8\u00b71 \u00b1 2\u00b74 nmol\/1). The remaining 8 pregnancies were predicted to be unaffected based on the results of amniotic fluid concentrations within the normal range. In each instance, the infant was normal. The results indicate that measurement of amniotic fluid 17OH\u2010progester\u2010one concentrations during the second trimester is an accurate prenatal test for 21\u2010hydroxylase deficiency. The results should be supplemented with determination of fetal sex by karyotype analysis on the amniotic fluid cells.<\/jats:p>","DOI":"10.1002\/pd.1970020204","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:12:28Z","timestamp":1172963548000},"page":"97-102","source":"Crossref","is-referenced-by-count":16,"title":["Prenatal diagnosis of congenital adrenal hyperplasia due to 21\u2010hydroxylase deficiency by amniotic fluid steroid analysis"],"prefix":"10.1002","volume":"2","author":[{"given":"I. A.","family":"Hughes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Laurence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.47.251.62"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90117-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970010107"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970010305"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92727-2"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.5.347"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90174-0"},{"key":"e_1_2_1_9_1","first-page":"583","article-title":"Neonatal endocrine and metabolic emergencies","volume":"9","author":"Hughes I. A.","year":"1980","journal-title":"Clin. Endocrinol. 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F.","year":"1979","journal-title":"Clin. Chem."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-44-5-934"},{"key":"e_1_2_1_21_1","first-page":"751","article-title":"Prenatal diagnosis of congenital adrenal hyperplasia","volume":"55","author":"Warsos S. L.","year":"1980","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_1_22_1","first-page":"109","article-title":"Comparison of two tests for heterozygosity in congenital adrenal hyperplasia (CAH)","volume":"91","author":"Weil J.","year":"1979","journal-title":"Acta Endocrinol."},{"key":"e_1_2_1_23_1","first-page":"557","article-title":"Unusual heterozygotes of congenital adrenal hyperplasia due to 21\u2010hydroxylase deficiency","volume":"87","author":"Zachmann M.","year":"1978","journal-title":"Acta Endocrinol. 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