{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:44:32Z","timestamp":1764171872084},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"vor","delay-in-days":8631,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1982,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experience indicates that the most likely explanation for a mixture of 46,XX\/46,XY cells in an amniotic fluid sample is that of maternal cell contamination and that a normal male child is to be expected at birth. We report the birth of a normal female child following prenatal diagnosis of such a mixture. Extensive postnatal studies failed to reveal an XY cell line. The possible sources of the XY cell line are discussed, as are the various techniques that were applied in an effort to discover it's origin. Cross\u2010contamination of samples could be ruled out and there was no evidence of an unsuspected twin pregnancy. It is clear from this case that not all 46,XX\/46,XY results obtained in amniotic fluid can be assumed to represent maternal cell contamination and some effort should be made to eliminate other potential sources for such a mixture.<\/jats:p>","DOI":"10.1002\/pd.1970020209","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:12:28Z","timestamp":1172963548000},"page":"127-131","source":"Crossref","is-referenced-by-count":13,"title":["46,XX\/46,XY chromosome complement in amniotic fluid cell culture followed by the birth of a normal female child"],"prefix":"10.1002","volume":"2","author":[{"given":"Alasdair","family":"Hunter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Brierley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darrell","family":"Tomkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"158","article-title":"Prenatal genetic diagnosis in 350 amniocenteses","volume":"48","author":"Crandall B. F.","year":"1976","journal-title":"Obset. Gynaecol."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1976.tb00047.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7350665"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80596-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00295700"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197901253000402"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1977.tb12500.x"},{"issue":"8","key":"e_1_2_1_9_1","first-page":"47","article-title":"An International System for Human Cytogenetic Nomenclature 1978","author":"ISCN","year":"1978","journal-title":"Birth Defects: Orig. Art. Ser."},{"key":"e_1_2_1_10_1","unstructured":"Medical Research Council of Canada(1977).Diagnosis of Genetic Disease by Amniocentesis during the Second Trimester of Pregancy Report No. 5 Ministry of Supply and Services Canada."},{"key":"e_1_2_1_11_1","first-page":"115","article-title":"Maternal cell contamination","volume":"34","author":"Mulchatry M. T.","year":"1976","journal-title":"Hum. Genet."},{"key":"e_1_2_1_12_1","series-title":"DHEW Publication No. (NIH) 78\u2013190","author":"National Institute of Child Health and Human Development","year":"1978"},{"key":"e_1_2_1_13_1","first-page":"519","volume-title":"Blood Groups in Man","author":"Race R. R.","year":"1975"},{"issue":"3","key":"e_1_2_1_14_1","first-page":"249","article-title":"Mosaicism in amniotic fluid cell cultures","author":"Rudd N. L.","year":"1977","journal-title":"Birth Defects: Orig. Art. 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