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In pregnancies complicated with anencephaly and spina bifida no significant difference was demonstrated for alpha\u20101\u2010antitrypsin, alpha\u20101\u2010antichymotrypsin and urokinase. Plasminogen was significantly lower (p &lt; 0.02) and plasmin significantly higher (<jats:italic>p<\/jats:italic> &lt; 0.001) than levels from normal amniotic fluid. Alpha\u20102\u2010macroglobulin, fibrinogen, FDP\u2010D and FDP\u2010E were detected only in pregnancies complicated with anencephaly and spina bifida.<\/jats:p>","DOI":"10.1002\/pd.1970030212","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:27:06Z","timestamp":1172964426000},"page":"145-149","source":"Crossref","is-referenced-by-count":1,"title":["Amniotic fluid fibrinolytic system in fetal neural tube defects"],"prefix":"10.1002","volume":"3","author":[{"given":"Michael","family":"Legge","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000205012"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1981.tb29764.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1975.tb01505.x"},{"key":"e_1_2_1_5_1","first-page":"76","article-title":"Methods for the determination of pre\u2010kallikrein in plasma, glandular kallikrein and urokinase","volume":"7","author":"Claesson G.","year":"1978","journal-title":"Haemostasis"},{"key":"e_1_2_1_6_1","first-page":"138","article-title":"Methods for determination of plasmin, antiplasmin and plasminogen by means of substrate S\u20102251","volume":"7","author":"Friberger P.","year":"1978","journal-title":"Haemostasis"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.4.995"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1976.tb00742.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1977.tb00926.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0002-9378(77)90624-X","article-title":"Amniotic fluid fibrinogen degradation products in the prenatal diagnosis of neural tube defects","volume":"128","author":"Kimball M. 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