{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T05:43:22Z","timestamp":1697780602271},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":8179,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1983,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In 40 pregnancies at risk for the Hurler syndrome 13 affected fetuses were detected by the demonstration of an \u03b1\u2010<jats:sc>L<\/jats:sc>\u2010iduronidase deficiency and an increased level of <jats:sup>35<\/jats:sup>S\u2010sulphate incorporation. The diagnoses were confirmed by the analysis of fetal tissues and\/or cultured fetal skin fibroblasts.<\/jats:p><jats:p>Microassays for \u03b1\u2010<jats:sc>L<\/jats:sc>\u2010iduronidase, using phenyl \u03b1\u2010<jats:sc>L<\/jats:sc>\u2010iduronide and more recently 4\u2013methyl\u2010umbelliferyl \u03b1\u2010<jats:sc>L<\/jats:sc>\u2010iduronide, enabled a reliable diagnosis to be made within 15 to 18 days after amniocentesis.<\/jats:p><jats:p><jats:sup>35<\/jats:sup>S\u2010sulphate incorporation has been a valuable adjunct in cases with a low (heterozygote) enzyme activity.<\/jats:p>","DOI":"10.1002\/pd.1970030302","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:33:06Z","timestamp":1172964786000},"page":"179-186","source":"Crossref","is-referenced-by-count":7,"title":["Prenatal diagnosis of the hurler syndrome: Report on 40 pregnancies at risk"],"prefix":"10.1002","volume":"3","author":[{"given":"W. 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