{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:20:15Z","timestamp":1789579215788,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":8179,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1983,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The concentration of human placental lactogen (hPL), pregnancy specific beta\u20101 glycoprotein (SP\u20101) and pregnancy\u2010associated plasma protein A (PAPP\u2010A) were analysed in consecutive serum samples from a patient who gave birth to a child with Cornelia de Lange syndrome. HPL and SP\u20101 were present in normal concentrations from week 20 to week 35 of gestation whereas PAPP\u2010A could not be detected in any of the samples examined. Immunohisto\u2010chemical examination of two placentae from Cornelia de Lange syndrome revealed normal localization of hPL and SP\u20101 but the absence of PAPP\u2010A from the syncytiotrophoblast. The significance of association between Cornelia de Lange syndrome and compromised synthesis of PAPP\u2010A is discussed.<\/jats:p>","DOI":"10.1002\/pd.1970030307","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:33:06Z","timestamp":1172964786000},"page":"225-232","source":"Crossref","is-referenced-by-count":63,"title":["Pregnancy\u2010associated plasma protein A: A possible marker in the classification and prenatal diagnosis of Cornelia de Lange syndrome"],"prefix":"10.1002","volume":"3","author":[{"given":"J. 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