{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T04:13:35Z","timestamp":1697775215330},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":7935,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Using a modified procedure by Solomons and Styner (1969), an evaluation of inorganic pyrophosphate (PPi) was performed on the amniotic fluid of two fetuses at risk for osteogenesis imperfecta (OI) at 14\u00bd weeks gestation. The parents of both cases had a previous child with OI, Type II. The normal control group at 14\u201316 weeks gestation had PPi values ranging from 22.0\u201359.2 ug\/100 ml, with a mean of 38.6\u00b19.51 ug\/100 ml. In each at\u2010risk fetus, the amniotic fluid PPi value was within normal range. The first baby was born phenotypically normal at term. Intrauterine radiographic and fetal sonograms were done on the second fetus at approximately 19 weeks gestation. Both showed evidence of OI, Type II. The pregnancy was terminated at 21 weeks. Radiologic studies of the aborted fetus were consistent with OI, Type II. Our results indicate that the evaluation of PPi levels in amniotic fluid is not the method of choice for prenatal diagnosis of IO.<\/jats:p>","DOI":"10.1002\/pd.1970040204","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T18:05:49Z","timestamp":1172945149000},"page":"109-112","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of inorganic pyrophosphate in amniotic fluid as a mode of prenatal diagnosis of osteogenesis imperfecta"],"prefix":"10.1002","volume":"4","author":[{"given":"Kenneth L.","family":"Garver","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam G.","family":"Blitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys","family":"Ibezim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra G.","family":"Marchese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores L.","family":"Pegram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita M.","family":"Hagins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wnjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"280","article-title":"Osteogenesis irnperfecta: A review of literature and report on three cases","volume":"77","author":"Awwaad S.","year":"1960","journal-title":"Arch, Pediatr."},{"key":"e_1_2_1_3_1","first-page":"1","article-title":"Fragilitas ossium hereditaria tarda (Ekman\u2010Lobstein disease)","volume":"340","author":"Caniggia A.","year":"1958","journal-title":"Actu. Med. Scand. (Supple.)"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5375.99"},{"issue":"3","key":"e_1_2_1_5_1","first-page":"125","article-title":"Midtrimester diagnosis of osteogenesis irnperfecta, type II","author":"Dinno N. D.","year":"1982","journal-title":"Birth Defects: Orig. Art. Ser."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(54)80315-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(75)90101-5"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1975.tb04398.x"},{"key":"e_1_2_1_9_1","volume-title":"Heritable Disorders of Connecrice Tissues","author":"McKusick V. A.","year":"1972"},{"issue":"6","key":"e_1_2_1_10_1","first-page":"1","article-title":"The classification of heritable disorders of connective tissue","author":"McKusick V. A.","year":"1975","journal-title":"Birth Defects: Orig. Art. Ser."},{"issue":"5","key":"e_1_2_1_11_1","first-page":"113","article-title":"Clinical variability in osteogenesis imperfecta: Variable expressivity or genetic heterogeneity","author":"Sillence D. O.","year":"1979","journal-title":"Birth Defects: Orig. Art. Ser."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.2.101"},{"key":"e_1_2_1_13_1","unstructured":"Solomons C. C. Armstrong D. A.(1976).Prenatal testing for osteogenesis imperfecta. Submitted to the 22nd Annual Meeting of the Orthopedic Research Society 88."},{"issue":"5","key":"e_1_2_1_14_1","first-page":"69","article-title":"Prenatal biochemistry of osteogenesis imperfecta","author":"Solomons C. C.","year":"1979","journal-title":"Birth Defects: Orig. Art. Ser."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02058674"},{"key":"e_1_2_1_16_1","first-page":"118","article-title":"Lethal short\u2010limbed dwarfism in Japan. Proceedings of the 5th International Conference of Birth Defects","volume":"426","author":"Tsuruta T.","year":"1977","journal-title":"Exerpta Medica"},{"issue":"12","key":"e_1_2_1_17_1","first-page":"296","article-title":"Congenital osteogenesis imperfecta","author":"Wilson M. G.","year":"1974","journal-title":"Birth Defects: Orig. Art. Ser."}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970040204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970040204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T21:44:47Z","timestamp":1697751887000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970040204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,3]]}},"alternative-id":["10.1002\/pd.1970040204"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970040204","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}