{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:04:31Z","timestamp":1792166671500,"version":"4.4.0"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":7874,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1984,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sixteen pregnancies at risk for Hunter syndrome have been monitored by amniocentesis. Iduronate 2\u2010sulphate sulphatase levels were measured in amniotic fluid, cultured amniotic fluid cells and cord blood. Thirteen of the pregnancies resulted in normal livebirths, two are continuing and one affected pregnancy was terminated. Reduced enzyme levels were observed in either amniotic fluid, cells or cord blood for four female fetuses. Such fetuses are likely to be carriers expressing reduced enzyme levels. The affected male fetus had reduced enzyme activity in amniotic fluid; insufficient cells were cultured for enzyme estimation, however no enzyme activity was detected in fetal liver after termination. Eight cord blood enzyme estimations have been performed, five confirming normal male infants.<\/jats:p>","DOI":"10.1002\/pd.1970040306","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:39:36Z","timestamp":1172965176000},"page":"195-200","source":"Crossref","is-referenced-by-count":9,"title":["Prenatal diagnosis of hunter syndrome"],"prefix":"10.1002","volume":"4","author":[{"given":"I. M.","family":"Archer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"Kingston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. S.","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(81)90274-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","unstructured":"Archer I. M. Young I. D. Rees D. W. Oladimeji A. Wusteman F. S. Harper P. S.(1983). Carrier detection in Hunter syndrome Am. J. Med. Genet. in press.","DOI":"10.1002\/ajmg.1320160111"},{"key":"e_1_2_1_4_1","first-page":"1419","article-title":"Direct vision chorion biopsy and chromosome\u2010specific DNA probes for determination of fetal sex in first\u2010trimester prenatal diagnosis","author":"Gosden J. R.","year":"1982","journal-title":"Lancet"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1979.tb01749.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80707-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970020305"},{"key":"e_1_2_1_9_1","first-page":"42","article-title":"Detection of Hunter heterozygotes by enzymatic analysis of hair roots","volume":"31","author":"Nwokoro N.","year":"1979","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_10_1","first-page":"1414","author":"Old J. M.","year":"1982","journal-title":"Lancet"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970040306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970040306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T02:26:17Z","timestamp":1697768777000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970040306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,5]]}},"alternative-id":["10.1002\/pd.1970040306"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970040306","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5]]}}}