{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:10Z","timestamp":1760188870730},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":7751,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1984,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the validity of mid\u2010trimester amniotic fluid testosterone and FSH in the diagnosis of fetal sex in abnormal fetuses and in twins.<\/jats:p><jats:p>It was found that the testosterone\/FSH ratio, but not the level of the individual hormones, was an excellent criterion for fetal sex diagnosis. In a control group of 32 female and 34 male fetuses, the testosterone\/FSH ratio was diagnostic. In two cases the values were indeterminate and fetal sex could not be predicted, but there were no false diagnoses.<\/jats:p><jats:p>The abnormalities of the fetuses were diagnosed by karyotype analyses or raised levels of \u03b1\u2010fetoprotein. It was found that neither autosomal trisomies nor X\u2010chromosome aneuploidy or neural tube defect interfered with the diagnostic value of the hormonal approach.<\/jats:p><jats:p>The twin study included 14 pairs, three of whom were discordant for sex. In all twins the fetal sex diagnosis was appropriate. In co\u2010twins of the same sex the hormone levels were very close to each other.<\/jats:p>","DOI":"10.1002\/pd.1970040505","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:50:17Z","timestamp":1172965817000},"page":"347-353","source":"Crossref","is-referenced-by-count":7,"title":["Prenatal sex diagnosis: Testosterone and fsh levels in mid\u2010trimester amniotic fluids"],"prefix":"10.1002","volume":"4","author":[{"given":"Dvorah","family":"Abeliovich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph R","family":"Leiberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Teuerstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/0002-9378(77)90034-5","article-title":"Amniotic fluid testosterone and folliclestimulating hormone in the determination of fetal sex","volume":"128","author":"Belsile S.","year":"1977","journal-title":"Am. Obstet. Gynecol."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000299465"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1982.03970390032010"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6836288"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320010207"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/0002-9378(77)90089-8","article-title":"Amniotic fluid testosterone in the prenatal determination of fetal sex","volume":"129","author":"Pirani B. B. K.","year":"1977","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6857252"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(80)90831-0"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970040505","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970040505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T21:04:19Z","timestamp":1697835859000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970040505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1984,9]]}},"alternative-id":["10.1002\/pd.1970040505"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970040505","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,9]]}}}