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This risk does not depend on paternal age, and it is independent of the type of the chromosome abnormality of the index child. Some geographical heterogeneities were detected. Therefore, the overall risk has to be considered as a rough estimate. The chromosome constitution of the abnormal fetus differed from that of the index patient in 21 of 41 cases. Several explanations for the higher risk have been discussed. If the index child had trisomy 18, 13 or a sex chromosome abnormality, the fetus tended to be a female. If the index child was a trisomy 21, the fetal sex ratio was normal.<\/jats:p>","DOI":"10.1002\/pd.1970040707","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:47:27Z","timestamp":1172965647000},"page":"81-95","source":"Crossref","is-referenced-by-count":65,"title":["Risk for chromosome abnormality at amniocentesis following a child with a non\u2010inherited chromosome aberration a european collaborative study on prenatal diagnoses 1981"],"prefix":"10.1002","volume":"4","author":[{"given":"Jon","family":"Stene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eeva","family":"Stene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareta","family":"Mikkelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"477","article-title":"Evidence for genetic control of nondisjunction in man","volume":"32","author":"Alfi O. 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