{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T23:26:01Z","timestamp":1698276361629},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":7144,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A complex chromosome rearrangement, apparently a balanced translocation involving chromosomes 4,6, 15 and 16, was found in cultured cells of amniotic fluid from a 32\u2013year\u2010old primigravida who requested amniocentesis for prenatal diagnosis because of a family history of mental retardation. Chromosome analysis of peripheral blood from both parents were normal.<\/jats:p><jats:p>The couple was counselled for the prenatal diagnosis of this <jats:italic>de novo<\/jats:italic> complex translocation and, subsequently, elected to terminate the pregnancy. Post\u2010mortem examination revealed a 23\u2013week fetus with intrauterine growth retardation. The identical chromosome rearrangement was subsequently confirmed in cultured fibroblasts from skin and cord obtained from the abortus.<\/jats:p><jats:p>To our knowledge, this is the first report where routine prenatal diagnosis revealed a fetus with a balanced complex chromosomal rearrangement involving four chromosomes of <jats:italic>de novo<\/jats:italic> origin.<\/jats:p>","DOI":"10.1002\/pd.1970060308","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T00:20:52Z","timestamp":1172967652000},"page":"211-216","source":"Crossref","is-referenced-by-count":16,"title":["Prenatal diagnosis of a <i>de novo<\/i> complex chromosomal rearrangement involving four chromosomes"],"prefix":"10.1002","volume":"6","author":[{"given":"Hyon Ju","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Perle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Bogosian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Greco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.16.3.215"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.14.2.141"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00272294"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.19.1.70"},{"key":"e_1_2_1_6_1","first-page":"85","article-title":"Deux translocations familiales survenues ensemble chez chacune de deux soeurs, l' une equilibree l'autre trisomique partielle lOq","volume":"15","author":"de Grouchy J.","year":"1972","journal-title":"Annales de Genetique"},{"issue":"5","key":"e_1_2_1_7_1","first-page":"181","article-title":"A new recognizable syndrome associated with a chromosomal abnormality","volume":"11","author":"Handmaker S. 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