{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T06:10:55Z","timestamp":1697955055205},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":7083,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An association has been reported between \u201clow\u201d maternal serum alpha\u2010fetoprotein (MSAFP) and fetal chromosome abnormalities, notably Down syndrome. We suggest the predictive value be used for genetic counselling when a \u201clow\u201d MSAFP is found, and present an illustrative risk table. It can also be seen that normal MSAFP in a woman may lower her age\u2010related risks below that previously defined as \u201chigh risk\u201d. However, until good estimates of sensitivity and specificity are available from prospective, population based studies, patients should be told that any risk estimates are rough approximations. When good estimates are available, use of age risks alone may become obsolete.<\/jats:p>","DOI":"10.1002\/pd.1970060403","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T00:28:45Z","timestamp":1172968125000},"page":"243-247","source":"Crossref","is-referenced-by-count":4,"title":["Implications of 'low maternal serum alpha\u2010fetoprotein levels: Are maternal age risk criteria obsolete?"],"prefix":"10.1002","volume":"6","author":[{"given":"Alice O.","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiang","family":"Llu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(84)80062-9"},{"key":"e_1_2_1_3_1","first-page":"161","article-title":"Low maternal serum AFP and Down syndrome","author":"Cowchock F. S.","year":"1984","journal-title":"Lancet"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)92389-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90585-3"},{"issue":"3","key":"e_1_2_1_6_1","first-page":"123","article-title":"Estimated rates of Down syndrome in live births by one\u2010year maternal age intervals for mothers aged 20\u201349 in a New York State study\u2010implications of the risk figures for genetic counselling and cost\u2010benefit analysis of prenatal diagnosis programs","volume":"13","author":"Hook E. B.","year":"1977","journal-title":"Birth Defects"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03330390038028"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90530-1"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970060403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970060403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T23:12:15Z","timestamp":1697929935000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970060403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,7]]}},"alternative-id":["10.1002\/pd.1970060403"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970060403","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7]]}}}