{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T22:58:48Z","timestamp":1756076328470},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":6899,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The history of amniocentesis utilization in the seventh largest state of the United States is documented from its inception in 1972 through the first half of 1984. Amniocentesis utilization ratios for Ohio residents aged \u2a7e35 have increased from 0.21 per cent (19\/9091) in 1972 to 23.4 per cent (1655\/7531) in 1983, representing an average annual growth rate of 43.1 per cent. Of the amniocenteses performed from January 1, 1978\u2013July 1, 1984, 71 per cent were referred for advanced maternal age (\u2a7e35), 15 per cent for maternal anxiety (30\u201334), 10 per cent for family history or previous child with a genetic defect, and 4 per cent for other reasons. Between 1978\u20101983 utilization by women 45 years of age was only 20 per cent higher than women 35 even though their risk of giving birth to a Down syndrome child was about one order of magnitude higher. In addition, various factors were tested as to whether they affected utilization of amniocentesis by women \u2a7e35 during 1978 1983. A strong correlation of +0.89 existed between county population size and utilization ratios. No difference in utilization was found between whites and nonwhites, regardless of county population size. When utilization ratios were compared separately between Protestants, Catholics and other religions in Ohio's most populated county, no statistical differences were found. From 1978\u2013July 1, 1984, the frequency of all cytogenetically abnormal chromosome results observed in Ohio amniocenteses to women \u2a7e35 was 2.48 per cent (187\/7536). Of these, 2.15 per cent (162\/7536) had unbalanced karyotypes. Future maximum amniocentesis utilization for women \u2a7e35 is estimated at 60\u201370 per cent.<\/jats:p>","DOI":"10.1002\/pd.1970070109","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T00:41:00Z","timestamp":1172968860000},"page":"51-65","source":"Crossref","is-referenced-by-count":11,"title":["Temporal changes in Ohio amniocentesis utilization during the first twelve years (1972\u20131983), and frequency of chromosome abnormalities observed"],"prefix":"10.1002","volume":"7","author":[{"given":"John M.","family":"Naber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl A.","family":"Huether","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth A.","family":"Goodwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90483-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90497-5"},{"key":"e_1_2_1_4_1","first-page":"846","article-title":"Clinical abservations: Cyctogenetic findings in over 2000 amniocenteses","volume":"129","author":"Allanson J.","year":"1983","journal-title":"Can. Med. Assoc. J."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1974.tb02092.x"},{"key":"e_1_2_1_6_1","first-page":"558","article-title":"Maternal\u2010age effect in aneuploidy: does altered embryonic selection play a role?","volume":"34","author":"Ayme S.","year":"1982","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970050305"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970050110"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-751860-2.50014-0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970020207"},{"key":"e_1_2_1_11_1","first-page":"2218","article-title":"The frequency of amniocentesis in pregnant women over the age of 35 years in Storstrom. A retrospective investigation of all pregnant women over the age of 35 years from 1.X.1978 to 1.X.1980","volume":"144","author":"Bo J.\u2010O.","year":"1982","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_1_12_1","first-page":"1057","article-title":"Evidence that altered embryonic selection contributes to maternal\u2010age effect in aneuploidy: a spurious contributable to pooling of heterogeneous data?","volume":"35","author":"Carothers A. D.","year":"1983","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320050405"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-198201000-00012"},{"key":"e_1_2_1_15_1","first-page":"2211","article-title":"Prenatal diagnosis in the County of Vejle in the period 1978\u201080","volume":"144","author":"Diernaes E.","year":"1982","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_1_16_1","unstructured":"Doherty R. Roghmann K.(1979). Knowledge attitudes and acceptance of prenatal diagnosis among women and physicians in the Rochester region. In: Porter I. Hoo E. (Eds).Service and Education in Medical Genetics 323\u2013334."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92314-6"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970040704"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90658-9"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197901253000402"},{"key":"e_1_2_1_21_1","unstructured":"Goodwin B. Huether C.(1985).Estimation and projection of Down's syndrome births for the United States and the effect of amniocentesis utilization. Unpublished."},{"key":"e_1_2_1_22_1","first-page":"1307","article-title":"Down syndrome rates and relaxed selection at older maternal ages","volume":"35","author":"Hook E. B.","year":"1983","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1001\/jama.1983.03330390038028","article-title":"Chromosomal abnormality rates at amniocentesis and in live born infants","volume":"249","author":"Hook E.","year":"1983","journal-title":"JAMA"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198112033052312"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.73.2.198"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420220209"},{"key":"e_1_2_1_27_1","first-page":"2215","article-title":"Utilization of offers of amniocentesis in the County of Funen in 1979 and 1980","volume":"144","author":"Kristoffersen S.","year":"1982","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_1_28_1","first-page":"1381","article-title":"Influence of obstetritcians' attitudes on their use of prenatal diagnosis for the detection of Down's syndrome","volume":"122","author":"Lippman\u2010Hand A.","year":"1980","journal-title":"Can. 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