{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:38:10Z","timestamp":1779907090914,"version":"3.53.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":6840,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reverse phase HPLC of radioactive globin chains has been compared to classical carboxy methyl cellulose chromatography for the prenatal diagnosis of \u03b2 thalassaemia. The two methods correlated highly (<jats:italic>r<\/jats:italic> = 0.97 <jats:italic>p<\/jats:italic> &lt; 0.0005) and provided an identical diagnosis for 40 fetal blood samples of fetuses homozygous or heterozygous for \u03b2 thalassaemia. The HPLC procedure was much faster and required fewer biochemical steps (no globin preparation). It was at least as accurate and more sensitive than the classical chromatography. A single column can be used for 150 analyses and is always ready to be used. Last but not least it is much less expensive than CMC chromatography.<\/jats:p>","DOI":"10.1002\/pd.1970070304","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T01:12:20Z","timestamp":1172970740000},"page":"171-178","source":"Crossref","is-referenced-by-count":3,"title":["Prenatal diagnosis of \u03b2 thalassaemia by reverse phase HPLC"],"prefix":"10.1002","volume":"7","author":[{"given":"Ph.","family":"Rouyer\u2010Fessard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Beuzard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vidaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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The Greek experience","volume":"18","author":"Loukopoulos D.","year":"1982","journal-title":"Birth Defects"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91324-1"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630268209083759"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92390-6"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1983.00001.x-i1"},{"key":"e_1_2_1_20_1","first-page":"1127","article-title":"Direct gene analysis of chorionic villi: A possible technique for first\u2010trimester antenatal diagnosis of haemoglobinopathies","author":"Williamson R.","year":"1981","journal-title":"Lancet"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970070304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970070304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T01:17:36Z","timestamp":1697851056000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970070304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,3]]}},"alternative-id":["10.1002\/pd.1970070304"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970070304","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,3]]}}}