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We report prenatal diagnosis of two fetuses with congenital contractures, markedly decreased fetal movement, and microcephaly due to severe holoprosencephaly. Such familial recurrence to phenotypically normal parents suggests a newly recognized autosomal recessive or X\u2010linked syndrome that is readily detectable by prenatal ultrasonography.<\/jats:p>","DOI":"10.1002\/pd.1970070905","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T01:15:23Z","timestamp":1172970923000},"page":"631-638","source":"Crossref","is-referenced-by-count":24,"title":["Prenatal diagnosis of a new syndrome: Holoprosencephaly with hypokinesia"],"prefix":"10.1002","volume":"7","author":[{"given":"Richard P.","family":"Morse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Rawnsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"Sargent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"John M.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320160211"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320170411"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688292"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80349-1"},{"key":"e_1_2_1_6_1","series-title":"BD, OAS","first-page":"133","volume-title":"Embryology and Pathogenesis and Prenatal Diagnosis","author":"Dimmick J. 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