{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T06:10:57Z","timestamp":1697955057354},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":6595,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1987,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal screening was carried out in Havana City, Cuba, as part of a National Medical Genetics Programme, in order to detect elevated alpha\u2010fetoprotein concentration in maternal serum (MS\u2010AFP). A total of 97 900 pregnant women between 15 and 19 weeks of pregnancy were tested from 1982 to 1985.<\/jats:p><jats:p>A double\u2010antibody\u2010sandwich technique was used.<\/jats:p><jats:p>173 malformed fetuses were detected. Confirmation was by ultrasonography, elevated AFP values in a second serum sample and in amniotic fluid and acetylcholinesterase. No termination of a normal pregnancy occurred. The screening of all pregnancies is easy, economical and useful for detecting not only fetuses suffering from open Neural Tube Defects (NTDs) and other severe disorders but also pregnancies at risk of further complications.<\/jats:p>","DOI":"10.1002\/pd.1970070908","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T01:15:23Z","timestamp":1172970923000},"page":"657-661","source":"Crossref","is-referenced-by-count":1,"title":["Prenatal diagnosis of neural tube by measurement of serum alpha\u2010fetoprotein defects in havana city"],"prefix":"10.1002","volume":"7","author":[{"given":"P. L.","family":"Rodriguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Heredero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Oliva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. O.","family":"Zaldivar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90026-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a071849"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970040105"},{"key":"e_1_2_1_5_1","first-page":"702","article-title":"Ultramicro ELISA for an alpha\u2010fetoprotein with the chamber analytical techniques","volume":"19","author":"Horn A.","year":"1981","journal-title":"J. Clio. Chem. Clin. Biomedichem."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00292665"},{"key":"e_1_2_1_7_1","first-page":"125","article-title":"Incidencia de los Defectors de Cierre del Tubo Neural","volume":"51","author":"Rodriguez L.","year":"1979","journal-title":"Rev. Cub. Ped."},{"issue":"12","key":"e_1_2_1_8_1","first-page":"1","article-title":"Quantification of Human AFP by EID","volume":"31","author":"Sizaret P.","year":"1971","journal-title":"Cancer Res."},{"key":"e_1_2_1_8_2","first-page":"1323","article-title":"Maternal serum alpha\u2010fetoprotein measurement in antenatal screening for anencephaly and spina bifida in early pregnancy;","author":"UK Collaborative Study","year":"1977","journal-title":"Lancet"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970070908","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970070908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T05:52:05Z","timestamp":1697867525000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970070908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1987,11]]}},"alternative-id":["10.1002\/pd.1970070908"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970070908","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11]]}}}