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Microvillar enzymes appeared in the amniotic fluid at the time of disappearance of the anal membrane, 12\u201313 weeks, and declined from the 18th week until the 24th week. The study of fetal tissues and fluids has shown that gamma\u2010glutamyltranspeptidase is mainly of liver origin. The significant decrease of the activities of these amniotic fluid enzymes has been the basis of prenatal diagnosis of cystic fibrosis. These assays may be useful for the diagnosis of certain digestive tract abnormalities at later stages of pregnancy.<\/jats:p>","DOI":"10.1002\/pd.1970080305","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T01:50:19Z","timestamp":1172973019000},"page":"189-198","source":"Crossref","is-referenced-by-count":56,"title":["Microvillar enzyme assays in amniotic fluid and fetal tissues at different stages of development"],"prefix":"10.1002","volume":"8","author":[{"given":"F.","family":"Muller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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