{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:17:26Z","timestamp":1790785046923,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":6382,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1988,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This controlled prospective study assesses the relative risks of first trimester chorionic villus sampling (CVS) versus mid\u2010trimester gentic amniocentesis (GA). CVS subjects and amnio\u2010centesis controls were comparable with regard to several confounding variables which might influence the risk of pregnancy loss including maternal age, smoking, alcohol consumption, gestational age at study entry, and history of vaginal bleeding or poor prior reproductive outcome. The most common indication for prenatal diagnosis was advanced maternal age (<jats:italic>n<\/jats:italic> = 511). In this subgroup, spontaneous abortion (&lt;24 weeks) occurred in 2\u00b79 per cent of CVS subjects versus 4\u22123 per cent of amniocentesis controls. The sum of spontaneous and therapeutic abortions (&lt;24 weeks) was identical (5\u00b73 per cent) in both groups. Therefore, intervention in the CVS group (i.e., therapeutic abortion for cytogenetic abnormalities) did not influence the observed risk of pregnancy loss. Overall perinatal mortality rates were also similar in both groups. No significant differences were identified for a number of pregnancy outcome parameters including 5 min Apgar score, birth weight, body length, head circumference, gestational age at delivery, preterm delivery, fetal growth retardation, congenital malformations, and neonatal complications. Preliminary results of this controlled prospective study suggest that chorionic villus sampling carries a low and acceptable risk.<\/jats:p>","DOI":"10.1002\/pd.1970080506","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T21:07:13Z","timestamp":1172956033000},"page":"355-366","source":"Crossref","is-referenced-by-count":27,"title":["First trimester chorionic villus sampling versus mid\u2010trimester genetic amniocentesis\u2010preliminary results of a controlled prospective trial"],"prefix":"10.1002","volume":"8","author":[{"given":"James P.","family":"Crane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi A.","family":"Beaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sau Wai","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90761-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90707-6"},{"key":"e_1_2_1_4_1","first-page":"2","volume":"22","author":"Jackson L. G.","year":"1987","journal-title":"CVS Newsl."},{"key":"e_1_2_1_5_1","first-page":"471","article-title":"Ultrasound signs in threatened abortion and their prognostic significance","volume":"65","author":"Mantoni M.","year":"1985","journal-title":"Obstet. Gynecoi."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970060609"},{"key":"e_1_2_1_7_1","first-page":"1","article-title":"Spontaneous abortion risks in man: data from reproductive histories collected in a medical genetics unit","volume":"16","author":"Warburton D.","year":"1964","journal-title":"Hum. Genet."},{"key":"e_1_2_1_8_1","first-page":"352","article-title":"Spontaneous abortion and pregnancy outcome after normal first trimester ultrasound examination","volume":"67","author":"Wilson R. D.","year":"1986","journal-title":"Obstet. Gynecoi."}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970080506","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970080506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T02:29:40Z","timestamp":1697855380000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970080506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,6]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1988,6]]}},"alternative-id":["10.1002\/pd.1970080506"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970080506","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,6]]}}}