{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:34:51Z","timestamp":1771580091870,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T00:00:00Z","timestamp":1132617600000},"content-version":"vor","delay-in-days":6353,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>From a total of 1312 diagnostic chorionic villus samplings (CVS) there were 22 which showed discordance between the karyotype of the chorionic villi and that of the fetus. This frequency was some 20\u2010fold higher than that reported at amniocentesis. In the majority of discordant cases, the fetal karyotype was normal while the placenta! karyotype was mosaic. In four cases, the placenta! karyotype was non\u2010mosaic (a trisomy 16, a monosomy X, and two tetraploids) while the fetal karyotype was normal. In one case, the placenta was trisomy 18 while the fetus was mosaic. There were two \u2018false\u2010negative\u2019 results where short\u2010term methods showed only normal cells while both long\u2010term cultures of chorionic villi and fetal cells were mosaic, in one 46,XY\/47.XXY and in the other 46,X Y\/47.X Y, + 21.<\/jats:p>","DOI":"10.1002\/pd.1970080610","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T01:41:28Z","timestamp":1172972488000},"page":"453-460","source":"Crossref","is-referenced-by-count":67,"title":["Extra embryonic\/fetal karyotypic discordance during diagnostic chorionic villus sampling"],"prefix":"10.1002","volume":"8","author":[{"given":"D. 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