{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:21:04Z","timestamp":1758925264350},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":6290,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hopes are held out for chorion villus sampling, a technique which is gaining more and more importance for the first trimester prenatal diagnosis of chromosomal aberrations and metabolic abnormalities. A variety of inherited skin diseases can be diagnosed postnatally and prenatally (in the second trimester) by ultrastructural diagnostic markers. For evaluation of prenatal diagnosis in the first trimester, we investigated chorionic villi derived from the trophoblast layer of the early pregnancy by light microscopy and conventional electron microscopy. The ultrastructure of the cellular layers covering the villi, i.e., the inner cytotrophoblast and the outer syncytiotrophoblast, as well as that of the connective tissue of the inner extraembryonic mesoderm, are thoroughly described in relation to the ultra\u2010structural changes in certain genodermatoses including epidermolyses and keratinization disorders. We found that chorionic villi have only a few of the characteristics differentiated in skin, and none of the structures which are relevant to the diagnosis of genodermatoses. In our view, the ultrastructural approach is not suitable for first trimester prenatal diagnosis of genodermatoses in chorionic villi.<\/jats:p>","DOI":"10.1002\/pd.1970080706","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T01:52:27Z","timestamp":1172973147000},"page":"511-524","source":"Crossref","is-referenced-by-count":3,"title":["Ultrastructure of first trimester chorionic villi with regard to the prenatal diagnosis of genodermatoses"],"prefix":"10.1002","volume":"8","author":[{"given":"Ingrid","family":"Hausser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrun","family":"Anton\u2010Lamprecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250810"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00295479"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","unstructured":"Anton\u2010Lamprecht I. (1988).Prenatal diagnosis of genodermatoses in:Dermatology in Five Continents. Proceedings of the XVII. World Congress of Dermatology Berlin May 24\u201329 1987. Springer 838\u2013843.","DOI":"10.1007\/978-3-642-83360-1_93"},{"key":"e_1_2_1_5_1","first-page":"146","volume-title":"Current Problems in Dermatology 16: Prenatal diagnosis of heritable skin diseases","author":"Anton\u2010Lamprecht I.","year":"1987"},{"key":"e_1_2_1_6_1","first-page":"184","volume-title":"Pranatale Diagnostik und Therapie","author":"Anton\u2010Lamprecht I.","year":"1987"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00388455"},{"key":"e_1_2_1_8_1","first-page":"120","volume-title":"Current Problems in Dermatology 16: Prenatal diagnosis of heritable skin diseases","author":"Arnold M.\u2010L.","year":"1987"},{"key":"e_1_2_1_9_1","volume-title":"Die Placenta des Menschen","author":"Becker V.","year":"1981"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp016173"},{"key":"e_1_2_1_11_1","first-page":"356","article-title":"Observations on human chorionic villi using the electron microscope","volume":"88","author":"Boyd J. D.","year":"1956","journal-title":"J. Anat."},{"key":"e_1_2_1_12_1","first-page":"586","article-title":"Diagnosis of fetal trisomy 21 in first trimester","author":"Brambati B.","year":"1983","journal-title":"Lancet"},{"key":"e_1_2_1_13_1","first-page":"52","volume-title":"Pranatale Diagnostik und Therapie","author":"Brusis E.","year":"1987"},{"key":"e_1_2_1_14_1","first-page":"127","volume-title":"Current Problems in Dermatology 17: Biology of heritable skin diseases","author":"Eady R. A. J.","year":"1987"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1980.tb00147.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)70075-7"},{"key":"e_1_2_1_17_1","first-page":"31","volume-title":"Chorion Villi Sampling","author":"Fabro S.","year":"1986"},{"key":"e_1_2_1_18_1","first-page":"111","volume-title":"Current Problems in Dermatology 17: Biology of heritable skin diseases","author":"Fine J.\u2010D.","year":"1987"},{"key":"e_1_2_1_19_1","first-page":"45","volume-title":"Current Problems in Dermatology 16: Prenatal diagnosis of heritable skin diseases","author":"Gedde\u2010Dahl T.","year":"1987"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198001103020205"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90831-0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00291562"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1974.tb02090.x"},{"key":"e_1_2_1_24_1","first-page":"117","article-title":"Fetal sex prediction of sex chromatin of chorion villi during early pregnancy","volume":"1","author":"Han A.","year":"1975","journal-title":"Clin. Med. J."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12355579"},{"key":"e_1_2_1_26_1","first-page":"465","article-title":"Elektronenoptische Untersuchungen an menschlichen Plazentazotten","volume":"91","author":"Herbst R.","year":"1969","journal-title":"Zentralbl. Gynakol."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.1979.18.5.329"},{"key":"e_1_2_1_28_1","first-page":"185","article-title":"Structure of the developing human embryonic and fetal skin","volume":"3","author":"Holbrook K. A.","year":"1984","journal-title":"Semin. Dermatoi."},{"key":"e_1_2_1_29_1","first-page":"94","volume-title":"Current Problems in Dermatology 16: Prenatal diagnosis of heritable skin diseases","author":"Holbrook K. A.","year":"1987"},{"key":"e_1_2_1_30_1","first-page":"181","volume-title":"Prdnatale Diagnostik und Therapie","author":"Holzgreve W.","year":"1987"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00234852"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1985.tb02400.x"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00305573"},{"key":"e_1_2_1_34_1","first-page":"100","volume-title":"Pranatale Diagnostik und Therapie","author":"Kleijer W. J.","year":"1987"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016347309157092"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90830-9"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90962-5"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091750104"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.101.2.363"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315904"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315950"},{"key":"e_1_2_1_42_1","volume-title":"The Developing Human","author":"Moore K. L.","year":"1982"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91324-1"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.53.1.234"},{"key":"e_1_2_1_45_1","first-page":"14","volume-title":"Current Problems in Dermatology 16: Prenatal diagnosis of heritable skin diseases","author":"Perry T. B.","year":"1987"},{"key":"e_1_2_1_46_1","volume-title":"Atlas der Embryologie","author":"Razek H. A.","year":"1978"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00824330"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91404-X"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90961-3"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00234853"},{"key":"e_1_2_1_51_1","volume-title":"Lehrbuch der Zoologie, Band I, Allgemeine Zoologie","author":"Siewing R.","year":"1980"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274761"},{"key":"e_1_2_1_53_1","first-page":"1745","article-title":"Development of dermal connective tissue in human embryonic and fetal skin","author":"Smith L. T.","year":"1982","journal-title":"SEM"},{"key":"e_1_2_1_54_1","first-page":"175","volume-title":"Current Problems in Dermatology 16: Prenatal diagnosis of heritable skin diseases","author":"T\u00f8nnesen T.","year":"1987"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070504"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091230202"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(64)90365-9"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970080706","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970080706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T17:15:44Z","timestamp":1697908544000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970080706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1002\/pd.1970080706"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970080706","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]}}}