{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T06:38:13Z","timestamp":1698215893253},"reference-count":7,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":6260,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Premature centromere separation (PCS) was detected in amniocytes after an amniocentesis was done because of markedly elevated maternal serum alpha\u2010fetoprotein values in a healthy primiparous young woman. PCS has been associated with the Roberts\u2010SC phocomelia syndrome (RS). By 23 weeks' gestation, ultrasonic evaluations did not reveal abnormal fetal development. The pregnancy continued and a male infant was born with mild manifestations of RS. PCS was confirmed in cord blood lymphocytes. This case illustrates that PCS, when detected in amniotic fluid cell cultures, requires a thorough evaluation.<\/jats:p>","DOI":"10.1002\/pd.1970080803","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T01:52:24Z","timestamp":1172973144000},"page":"565-569","source":"Crossref","is-referenced-by-count":20,"title":["Incidental detection of premature centromere separation in amniocytes associated with a mild form of Roberts syndrome"],"prefix":"10.1002","volume":"8","author":[{"given":"Wayne S.","family":"Stanley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Shashidhar","family":"Pai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Edgar O.","family":"Horger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yongshan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S.","family":"McNeal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1975.tb00631.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00489985"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320140319"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320240410"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00286646"},{"key":"e_1_2_1_7_1","first-page":"A85","article-title":"Roberts syndrome (RS) without phocomelia or cleft lip\/palate","volume":"41","author":"Stamberg J.","year":"1987","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/13816818509004111"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970080803","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970080803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T14:14:08Z","timestamp":1697897648000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970080803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10]]},"references-count":7,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1988,10]]}},"alternative-id":["10.1002\/pd.1970080803"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970080803","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10]]}}}