{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T10:55:58Z","timestamp":1698058558018},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":6078,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A French couple with an individual risk of carrying the cystic fibrosis (CF) mutation of 1\/2 sought genetic counselling. From the DNA haplotypes generated by XV\u20102c and KM\u201019 RFLPs, it could be deduced that only one subject was a carrier, lowering the risk of having a CF baby from 1\/16 to 1\/200. The strong linkage disequilibrium between these RFLPs and the CF allele observed in France reduced the risk to 1\/1600.<\/jats:p>","DOI":"10.1002\/pd.1970090410","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T02:43:58Z","timestamp":1172976238000},"page":"297-300","source":"Crossref","is-referenced-by-count":1,"title":["Usefulness of linkage disequilibrium of KM\u201019 and XV\u20102c DNA probes for genetic counselling in a high\u2010risk cf family"],"prefix":"10.1002","volume":"9","author":[{"given":"J. C.","family":"Chomel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Haliassos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Tesson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kitzis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801073180114"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/326840a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91553-9"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/15.22.9611"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/318380a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2997931"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","unstructured":"Vidaud M. Kitzis A. Ferec C. Bozon D. Dumur V. Giraud G. David F. Pascal O. Auvinet M. Morel Y. Andre J. Chomel J. C. Saleun J. P. Farriaux J. P. Roussel Ph. Labbe A. Dastugue B. Lucotte B. Monnier N. Goossens M. Feingold J. Kaplan J. C.(1989). Confirmation of linkage disequilibrium between haplotype B (XV\u20102c: allele 1 KM\u201019: allele 2) and cystic fibrosis gene in the French population Hum. Genet. in press.","DOI":"10.1007\/BF00293899"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/318384a0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/318382a0"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970090410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970090410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T02:36:53Z","timestamp":1697942213000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970090410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,4]]}},"alternative-id":["10.1002\/pd.1970090410"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970090410","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4]]}}}