{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:07:07Z","timestamp":1761718027330},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":5925,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Over a four\u2010year period, 140 pregnancies with different malformations detected by ultrasound were examined cytogenetically. Gestational age ranged from 13 to 36 weeks. Twenty\u2010six fetuses (18.6 per cent) had abnormal karyotypes, including trisomies, triploidy, monosomy X, and structural anomalies. Similar malformations were found in fetuses with different chromosomal anomalies, indicating that the types of malformations are not specific for particular chromosomal anomalies.<\/jats:p><jats:p>Chromosomal analysis was performed on amniotic fluid culture and by direct karyotyping of placental biopsies. Direct karyotyping is suggested to be the most rapid approach, especially if sonographic anomalies are detected close to the 24th week of gestation, shortly before delivery, and in cases of significant oligohydramnios.<\/jats:p>","DOI":"10.1002\/pd.1970090902","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T03:39:06Z","timestamp":1172979546000},"page":"605-612","source":"Crossref","is-referenced-by-count":16,"title":["Abnormal pregnancy sonogram and chromosomal anomalies: Four years' experience with rapid karyotyping"],"prefix":"10.1002","volume":"9","author":[{"given":"M.","family":"Hentemann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Rauskolb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ulbrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320230406"},{"key":"e_1_2_1_3_1","unstructured":"Bartels I. B\u00e4hr S. Holland U. Sch\u00fcbbe I. Hansmann I. Gellert G. Werner L. Rauskolb R.(1989). Second and third trimester placental biopsy karyotyping Excerpta Med. in press."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(87)80279-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90165-2"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970080610"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970060603"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1988.tb04264.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb03070.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-00580-4_8"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6867735"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1988.tb02864.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970060507"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970080205"},{"key":"e_1_2_1_15_1","first-page":"881","article-title":"Prenatal sonographic detection of fetal facial malformations","volume":"23","author":"Meizner I.","year":"1987","journal-title":"Isr. 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Trimenon","volume":"21","author":"Rauskolb R.","year":"1988","journal-title":"Gyn\u00e4kologe"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970040509"},{"key":"e_1_2_1_22_1","first-page":"330","volume-title":"Prenatal Diagnosis","author":"Rehder H.","year":"1979"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970080203"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274761"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070911"},{"key":"e_1_2_1_26_1","first-page":"15","article-title":"Abnormal pregnancy sonogram: selective indication for fetal karyotype","volume":"69","author":"Williamson R. A.","year":"1987","journal-title":"Obstet. 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