{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:17:28Z","timestamp":1759565848092},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":5895,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In two cases of prenatally detected cystic hygroma with oligohydraminos, successful cytogenetic diagnosis of Turner syndrome was achieved using cells obtained from direct aspiration of the cystic hygroma. Exceptionally high levels of alpha\u2010fetoprotein were found in the cystic hygroma fluid, as might be expected. However, the maternal serum alpha\u2010fetoprotein levels were within normal limits. Elevated alpha\u2010fetoprotein levels in \u2018amniotic fluid\u2019 noted previously in the literature may have resulted because of inadvertent tapping of the cystic hygroma. It is clear from our cases that maternal serum levels of alpha\u2010fetoprotein will not necessarily be elevated and will not serve as a screening mechanism for cystic hygromas.<\/jats:p>","DOI":"10.1002\/pd.1970091002","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T22:05:39Z","timestamp":1172959539000},"page":"683-689","source":"Crossref","is-referenced-by-count":19,"title":["Prenatal diagnosis of turner syndrome using cells cultured from cystic hygromas in two pregnancies with normal maternal serum alpha\u2010fetoprotein"],"prefix":"10.1002","volume":"9","author":[{"given":"Wendy L.","family":"Golden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard F.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M.","family":"Gustashaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majida N.","family":"Jassani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92973-2"},{"key":"e_1_2_1_3_1","first-page":"51","article-title":"Prenatal detection of a familial nuchal bleb simulating encephalocele","volume":"15","author":"Bieber F. 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