{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:12:21Z","timestamp":1762521141119},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":5864,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal diagnosis in a kindred with the Opitz (BBB) syndrome is presented. The inheritance is consistent with either autosomal dominant inheritance with sex limited expression or X\u2010linked inheritance. The abnormalities in the kindred consist of hypertelorism, hypospadias, ambiguous genitalia, urocolic fistula, imperforate anus, mental retardation, diaphragmatic hernia, and malrotation with volvulus. A male fetus at 19 weeks was found by ultrasound to have hypertelorism and hypospadias with a small phallus consistent with the syndrome. The diagnosis was confirmed by pathologic examination after pregnancy termination. This is the first report of prenatal diagnosis of Opitz syndrome by ultrasonographic demonstration of hypertelorism and hypospadias in the second trimester.<\/jats:p>","DOI":"10.1002\/pd.1970091107","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T22:11:22Z","timestamp":1172959882000},"page":"783-793","source":"Crossref","is-referenced-by-count":20,"title":["Prenatal diagnosis of Opitz (BBB) syndrome in the second trimester by ultrasound detection of hypospadias and hypertelorism"],"prefix":"10.1002","volume":"9","author":[{"given":"C.","family":"Hogdall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Siegel\u2010Bartelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Toi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90306-5"},{"key":"e_1_2_1_3_1","first-page":"82","article-title":"Familial telecanthus with associated congenital anomalies","volume":"2","author":"Christian J. 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M.","year":"1969","journal-title":"Birth Defects"},{"key":"e_1_2_1_12_1","first-page":"86","article-title":"The BBB syndrome\u2013familial telecanthus with associated congenital anomalies","volume":"2","author":"Opitz J. M.","year":"1969","journal-title":"Birth Defects"},{"key":"e_1_2_1_13_1","first-page":"62A","article-title":"Features of the G (Opitz\u2013Frias) and BBB (hypospadias\u2013hypertelorism) syndrome in one family\u2013are they a single disorder? (Abstract)","volume":"30","author":"Parisan S.","year":"1978","journal-title":"Am. J. Hum. 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