{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:56:26Z","timestamp":1761101786646},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":5772,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Data on maternal serum alpha\u2010fetoprotein (AFP) levels at 13\u201324 weeks' gestation in 46 twin pregnancies with open neural tube defects (22 with anencephaly, 24 with open spina bifida) and 169 unaffected twins were used to estimate the detection and false\u2010positive rates associated with different cut\u2010off levels. Using the conventional cut\u2010off level of 2\u00b75 multiples of the median (MoM) for unaffected singleton pregnancies of the same gestation and laboratory, the detection rate in twins was 99 per cent for anencephaly and 89 per cent for open spina bifida, with a false\u2010positive rate of 30 per cent. Using a 5\u00b70 MoM cut\u2010off level to maintain a similar false\u2010positive rate to that found among singleton pregnancies at 16\u201318 weeks' gestation (about 3 per cent), the detection rate was 83 per cent for anencephaly and 39 per cent for open spina bifida. Estimates are provided of the odds of having an affected twin pregnancy given a positive AFP result as well as the odds for individual women with a raised AFP level.<\/jats:p>","DOI":"10.1002\/pd.1970100202","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T03:43:12Z","timestamp":1172979792000},"page":"71-77","source":"Crossref","is-referenced-by-count":20,"title":["MATERNAL SERUM ALPHA\u2010FETOPROTEIN SCREENING FOR OPEN NEURAL TUBE DEFECTS IN TWIN PREGNANCIES"],"prefix":"10.1002","volume":"10","author":[{"given":"H.","family":"Cuckle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Wald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M.","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Ferguson\u2010Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Milford","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M.","family":"Barbour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Laurence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Norgaard\u2010Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1987.tb03115.x"},{"key":"e_1_2_1_3_1","first-page":"1323","article-title":"Maternal serum alpha\u2010fetoprotein measurement in antenatal screening for anencephaly and spina bifida in early pregnancy","year":"1977","journal-title":"Lancet"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.36.2.87"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1982.tb05032.x"},{"key":"e_1_2_1_6_1","first-page":"651","article-title":"Amniotic fluid alpha\u2010fetoprotein measurement in the antenatal diagnosis of anencephaly and open spina bifida in early pregnancy","year":"1979","journal-title":"Lancet"},{"key":"e_1_2_1_7_1","volume-title":"Prenatal Diagnosis","author":"Wald N.","year":"1987"},{"key":"e_1_2_1_8_1","volume-title":"Textbook of Ultrasound in Obstetrics and Cynecology","author":"Wald N. 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Sante Publique"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970100202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970100202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T15:12:46Z","timestamp":1697987566000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970100202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,2]]}},"alternative-id":["10.1002\/pd.1970100202"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970100202","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2]]}}}