{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:44:59Z","timestamp":1756993499622},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":5744,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The value of determination of maternal serum of alpha\u2010fetoprotein (MSAFP) concentration in i he second trimester is well established. In addition to open neural tube defects, pregnancies associated with elevated second\u2010trimester MSAFP have been shown to be at increased risk for a variety of problems, including low birth weight, preterm delivery, and pregnancy\u2010induced hypertension (PIH). We evaluated the potential usefulness of MSAFP in the early third trimester. MSAFP concentration was determined in over 200 women at the time of glucose screening. Results were analysed with regard to gestational age at sampling, maternal weight, race, diabetes, and presence of twins. MSAFP was twice as high in twin gestation, but not affected by race or the presence of diabetes. In contrast to levels in early gestation, third\u2010trimester MSAFP does not appear to be predictive of preterm delivery, low birth weight, or PIH.<\/jats:p>","DOI":"10.1002\/pd.1970100308","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T03:40:32Z","timestamp":1172979632000},"page":"183-188","source":"Crossref","is-referenced-by-count":5,"title":["The value of early third\u2010trimester maternal serum alpha\u2010fetoprotein determination"],"prefix":"10.1002","volume":"10","author":[{"given":"William F.","family":"O'Brien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Sternlicht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Knuppel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Montenegro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(83)91091-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1980.tb05008.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970020108"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408368109105870"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92876-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0002-9378(83)91058-X","article-title":"Elevated maternal serum alpha\u2010fetoprotein associated with Potter's syndrome","volume":"146","author":"Freiling E. N.","year":"1987","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(84)90530-1"},{"key":"e_1_2_1_9_1","first-page":"157","volume-title":"Alpha\u2010Fetoprotein and Congenital Disorders","author":"Misejewski G. J.","year":"1985"},{"key":"e_1_2_1_10_1","first-page":"253","article-title":"Maternal and fetal alpha\u2010fetoprotein (AFO) levels at term","volume":"64","author":"Obiekwe B. C.","year":"1985","journal-title":"Ada Obstet. Gynecol. Scand."},{"key":"e_1_2_1_11_1","first-page":"994","article-title":"Elevated maternal serum alpha\u2010fetoprotein in triploidy","volume":"71","author":"O'Brien W. F.","year":"1988","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90622-2"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1976.tb00725.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90220-7"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-197310000-00023"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb01106.x"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970100308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970100308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T15:18:27Z","timestamp":1697987907000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970100308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,3]]}},"alternative-id":["10.1002\/pd.1970100308"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970100308","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3]]}}}