{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:30:34Z","timestamp":1789054234720,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":5713,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A set of 21 early maternal serum samples (19 first\u2010trimester and two at 14 weeks) from pregnancies resulting in a child with Down syndrome was matched for gestation and length of storage with 63 samples from unaffected pregnancies. The concentrations of alpha\u2010fetoprotein (AFP), unconjugated oestriol (uE<jats:sub>3<\/jats:sub>), human chorionic gonadotrophin (hCG), pregnancy\u2010specific \u03b2<jats:sub>1<\/jats:sub>\u2013glycoprotein (SP<jats:sub>1<\/jats:sub>), and placental alkaline phosphatase (PALP) were measured. The ratios of the medians for Down syndrome pregnancies compared with the medians for controls were AFP 0\u00b771, uE<jats:sub>3<\/jats:sub> 0\u00b767, hCG 1\u00b743, SP<jats:sub>1<\/jats:sub> 0\u00b779, and PALP 0\u00b792. Although the differences between the medians for affected and unaffected pregnancies were not significant, the trends for AFP, uE<jats:sub>3<\/jats:sub>, and hCG confirm earlier findings on first\u2010trimester samples.<\/jats:p>","DOI":"10.1002\/pd.1970100406","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T03:55:56Z","timestamp":1172980556000},"page":"245-251","source":"Crossref","is-referenced-by-count":81,"title":["First\u2010trimester maternal serum biochemical indicators in Down syndrome"],"prefix":"10.1002","volume":"10","author":[{"given":"D. J. H.","family":"Brock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilias","family":"Barron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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