{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:37:22Z","timestamp":1760204242477},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":5683,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radial\u2010ray reduction malformations (RRRMs) may occur isolated or in association with other anomalies. The data of seven fetuses born with RRRMs were collected. Six fetuses had associated lethal abnormalities of the central nervous system, urogenital system, and\/or heart, detected by ultrasound. In five cases, it was possible to establish the precise diagnosis, enabling an informed prognosis and subsequent genetic counselling. The diagnoses were: Edwards syndrome (<jats:italic>n<\/jats:italic>=3), VACTERL association (<jats:italic>n<\/jats:italic>=1), and Poland\u2010Moebius\u2010like complex (<jats:italic>n<\/jats:italic>= 1). In two cases, a complete diagnosis was not possible because of inadequate evaluation of these fetuses before and\/or after birth. A proposal is given for the diagnostic approach for infants with RRRMs detected in the antenatal period by means of ultrasonography.<\/jats:p>","DOI":"10.1002\/pd.1970100502","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T03:54:21Z","timestamp":1172980461000},"page":"279-288","source":"Crossref","is-referenced-by-count":28,"title":["Prenatal ultrasonographic diagnosis of radial\u2010ray reduction malformations"],"prefix":"10.1002","volume":"10","author":[{"given":"Jozien T. J.","family":"Brons","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J.","family":"Van Der Harten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman P.","family":"Van Geijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juri W.","family":"Wladimiroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martinus F.","family":"Niermeuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Lindhout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Stuart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris J. L. M.","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico F. Th","family":"Arts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"135","article-title":"Reduction malformations and chromosome anomalies","volume":"125","author":"Bofinger M. K.","year":"1973","journal-title":"Am. J. Dis. 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