{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T08:11:36Z","timestamp":1777104696206,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":5379,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A case of agnathia\u2010astomia\u2010holoprosencephaly with prenatal ultrasound diagnosis at 23 weeks is reported and discussed. This lethal neurocristopathy, well known in mammalians, is rarely observed in humans. Prenatal diagnosis features are intrauterine growth retardation, mandible absence or major hypoplasia, holoprosencephaly, cyclopia or hypotelorism, and in some instances frontal proboscis. This malformation is usually sporadic, but may be genetically determined as an autosomal recessive trait, since two cases in the same sibship have been reported.<\/jats:p>","DOI":"10.1002\/pd.1970110310","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T05:34:34Z","timestamp":1172986474000},"page":"199-203","source":"Crossref","is-referenced-by-count":17,"title":["Astomia\u2010agnathia\u2010holoprosencephaly association. Prenatal diagnosis of a new case"],"prefix":"10.1002","volume":"11","author":[{"given":"M.","family":"Rolland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. F.","family":"Sarramon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80645-7"},{"key":"e_1_2_1_3_1","unstructured":"Bixler D. Ward R. Gale J. D.(1985). Agnathia\u2010holoprosencephaly: a developmental field complex involving face and brain report of 3 cases J. Craniofac. Genet. Dev. Biol. Suppl. 1 241\u2013249."},{"key":"e_1_2_1_4_1","first-page":"107","article-title":"Cyclopiaotocephaly association: a new case of the most severe variant of agnathia\u2010holoprosencephaly complex","volume":"7","author":"Carles D.","year":"1987","journal-title":"J. Craniof. Gen. Dev. Biol."},{"key":"e_1_2_1_5_1","first-page":"5","article-title":"La crete neurale cephalique et les malformations cervico\u2010faciales humaines","volume":"19","author":"Couly G.","year":"1983","journal-title":"Rev. Pediatr."},{"key":"e_1_2_1_6_1","first-page":"23","article-title":"Some abnormal patterns of development in the cranio\u2010facial region","volume":"15","author":"Johnston M. C.","year":"1979","journal-title":"Birth Defect Orig. Artie. Ser."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320290303"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1979.tb00854.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80337-5"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230111"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320140411"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000540303"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970110310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970110310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T17:36:24Z","timestamp":1695836184000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970110310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,3]]}},"alternative-id":["10.1002\/pd.1970110310"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970110310","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,3]]}}}