{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T11:16:28Z","timestamp":1698146188624},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":5104,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal diagnosis of haemoglobin disorders is accepted to be a useful procedure to avoid births of infants with homozygous diseases. Advances in sampling and molecular techniques, such as polymerase chain reaction (PCR) and chorionic villus sampling (CVS), have made earlier and safer first\u2010trimester prenatal diagnosis possible. However, these procedures need previous studies of at\u2010risk couples, which can be very time\u2010consuming when a number of different \u03b2\u2010thalassaemia mutations occur in the region. We describe the possibility of making a first\u2010trimester prenatal diagnosis by cordocentesis and fetal blood analysis at the 12th week of gestation. We found no statistically significant difference (<jats:italic>p<\/jats:italic>&gt;0.05) between \u03b2\/\u03b3 values in fetuses at the 12th and 18th weeks of gestation. In seven affected fetuses aborted at the 12th week of gestation, the diagnosis was confirmed in all cases by PCR analysis. These findings suggest that early cordocentesis could be an alternative procedure to CVS and PCR analysis.<\/jats:p>","DOI":"10.1002\/pd.1970111204","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T01:08:35Z","timestamp":1172970515000},"page":"899-904","source":"Crossref","is-referenced-by-count":6,"title":["Prenatal diagnosis of haemoglobin disorders by cordocentesis at 12 weeks' gestation"],"prefix":"10.1002","volume":"11","author":[{"given":"F.","family":"Di Trapani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Marino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"D'Alcamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Abate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"D'Agostino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lauricella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Music\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sammarco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Maggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Modell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1182\/blood.V64.2.329.329","article-title":"Advances in the prenatal diagnosis of haematological diseases","volume":"84","author":"Alter B. P.","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(76)90748-1"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1182\/blood.V71.5.1357.1357","article-title":"A simple approach to prenatal diagnosis of \u03b2\u2010thalassemia in a geographic area where multiple mutations occur","volume":"71","author":"Cai S. P.","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_5_1","volume-title":"Practical Haematology","author":"Dacie J. 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B.","year":"1976","journal-title":"Postgrad. Med. J."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(87)80344-7"},{"key":"e_1_2_1_13_1","first-page":"23","article-title":"First\u2010trimester foetal blood sampling","volume":"19","author":"Orlandi F.","year":"1988","journal-title":"Acta Eur. Fert."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970100703"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198903093201001"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970111204","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970111204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T18:18:51Z","timestamp":1698085131000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970111204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1991,12]]}},"alternative-id":["10.1002\/pd.1970111204"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970111204","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]}}}