{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T05:50:26Z","timestamp":1771998626007,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":5104,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During 1988 and 1989, 3565 women booked under consultants who performed an ultrasound scan at booking, whilst 4984 booked under consultants who performed a formal mid\u2010trimester scan between 16 and 18 weeks. All significant anomalies diagnosed prenatally and in the neonatal period were recorded, the incidence in each group being 12.9\/1000 and 9.83\/1000, respectively (NS).<\/jats:p><jats:p>The sensitivity of diagnosis before 20 weeks was 45 per cent in the \u2018mid\u2010trimester\u2019 group (kappa 0.62) compared with 30 per cent in the \u2018booking\u2019 group (kappa 0.46), overall sensitivity of prenatal diagnosis, however, being similar in both groups (63 vs. 65 per cent, kappa 0.77 vs. 0.79). Cardiac anomalies were the single largest group which were not detected equally prenatally in both groups.<\/jats:p><jats:p>This study shows that formal mid\u2010trimester scanning leads to anomalies being detected significantly earlier in the antenatal period. Although not statistically significant, three lethal anomalies were missed prenatally in the \u2018booking\u2019 group which we would have expected to diagnose on a mid\u2010trimester scan. These figures are discussed in the light of previous reports.<\/jats:p>","DOI":"10.1002\/pd.1970111205","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T01:08:35Z","timestamp":1172970515000},"page":"905-914","source":"Crossref","is-referenced-by-count":28,"title":["Comparative audit of booking and mid\u2010trimester ultrasound scans in the prenatal diagnosis of congenital anomalies"],"prefix":"10.1002","volume":"11","author":[{"given":"G.","family":"Constantine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"McCormack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198803000-00009"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6537.1717"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.59.3.356"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90492-6"},{"key":"e_1_2_1_6_1","first-page":"747","article-title":"Routine or selective ultrasound examinations in early pregnancy","volume":"5","author":"Belfrage P.","year":"1987","journal-title":"Obstet. 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Diagnostic Ultrasound in Pregnancy: Consensus Statement","author":"NIH","year":"1984"},{"key":"e_1_2_1_20_1","unstructured":"RCOG(1984).Royal College of Obstetrics and Gynaecology Working Party on Routine Ultrasound Examination in Pregnancy Report London."},{"key":"e_1_2_1_21_1","unstructured":"RCOG(1987). Report of the Joint Ultrasound Group of the Royal College of Obstetricians and Gynaecologists and Royal College of Radiologists March 1987."},{"key":"e_1_2_1_22_1","volume-title":"Prenatal Diagnosis of Congenital Anomalies","author":"Romero R.","year":"1988"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198906000-00008"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(90)90045-3"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb01346.x"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90636-8"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970111205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970111205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T18:18:56Z","timestamp":1698085136000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970111205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1991,12]]}},"alternative-id":["10.1002\/pd.1970111205"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970111205","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,12]]}}}