{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:37:00Z","timestamp":1760204220607},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":4829,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amiodarone treatment in pregnancy might be difficult to handle because of the long half\u2010life of the drug (14\u201328 days up to 2 months) and because it reduces maternal and neonatal thyroid activity. Although short\u2010term use in pregnancy has been described in cases of fetal supraventricular tachycardia, there are few reports on the chronic use of the drug. In this paper we describe our experience with amiodarone treatment in two pregnant sisters with familial dilatative cardiomyopathy and ventricular malignant extrasystole. Prolonged administration of amiodarone (400\u2013200 mg\/die) since the beginning of pregnancy did not have any adverse effects; maternal and neonatal thyroid function was normal, as was the neurological and motor development of the neonates.<\/jats:p>","DOI":"10.1002\/pd.1970120903","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:27:05Z","timestamp":1172989625000},"page":"705-708","source":"Crossref","is-referenced-by-count":10,"title":["Amiodarone treatment in pregnancy for dilatative cardiomyopathy with ventricular malignant extrasystole and normal maternal and neonatal outcome"],"prefix":"10.1002","volume":"12","author":[{"given":"Herbert","family":"Valensise","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concettina","family":"Civitella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe Gioele","family":"Garzetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Romanini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(87)80095-4"},{"key":"e_1_2_1_3_1","first-page":"79","article-title":"Trans\u2010placental passage of amiodarone: electrocardiographic and pharmacological evidence in a newborn","volume":"12","author":"Candelpergher G.","year":"1982","journal-title":"G. Ital. Cardiol."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1988.tb10717.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(88)90285-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1991.01030162.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(91)90085-F"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1991.01040286.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)91070-8"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.67.1.51"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.61.711.75"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a062380"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970120903","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970120903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T09:55:52Z","timestamp":1698054952000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970120903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1002\/pd.1970120903"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970120903","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}