{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:23:35Z","timestamp":1757705015335},"reference-count":6,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":4829,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For pregnancies less than 17 menstrual weeks, increasing amounts of nuchal fluid increase the risks of chromosome abnormalities with localized nuchal fluid, diffuse nuchal fluid, cystic hygroma, and fetal hydrops having chromosomal risks of 12, 23, 50, and 78 per cent, respectively. The ultrasound appearance of localized or diffuse nuchal fluid is not a specific discriminator, but a fluid depth of greater than or equal to 5 mm may be an indicator of increased risk of fetal chromosomal abnormalities. If the fluid depth is less than 5 mm, there is a stronger negative predictive value and negative likelihood risk of a fetal chromosome abnormality. Gestational age did not improve the fluid depth predictive value. Differentiation of physiological from pathological requires chromosome analysis, serial ultrasound evaluation, and good clinical examination as a newborn and possibly as a young child. Long\u2010term follow\u2010up of those cases identified with resolving nuchal fluid abnormalities is not available and is required for a complete understanding of physiological and pathological aetiologies. Genetic counselling for fetal nuchal fluid would be recommended.<\/jats:p>","DOI":"10.1002\/pd.1970120908","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:27:05Z","timestamp":1172989625000},"page":"755-763","source":"Crossref","is-referenced-by-count":22,"title":["Fetal nuchal fluid\u2010physiological or pathological?\u2014In pregnancies less than 17 menstrual weeks"],"prefix":"10.1002","volume":"12","author":[{"given":"R. D.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Venir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. F.","family":"Farquharson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198310063091403"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320330313"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970101004"},{"key":"e_1_2_1_5_1","first-page":"611","volume-title":"Clinics in Perinatology","author":"Edwards M. J.","year":"1990"},{"key":"e_1_2_1_6_1","volume-title":"Sequential Atlas of Human Congenital Malformations. Observation of Embryos, Fetuses and Newborns","author":"Nishimura H.","year":"1976"},{"key":"e_1_2_1_7_1","first-page":"323","article-title":"The embryonic development of the main lymphatics in man","volume":"18","author":"Van der Putte P. C. J.","year":"1980","journal-title":"Acta Morphol. Neerl.\u2010Scand."}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970120908","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970120908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T09:56:30Z","timestamp":1698054990000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970120908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":6,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1002\/pd.1970120908"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970120908","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}