{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:27Z","timestamp":1761058647125},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":4768,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the context of a prospective study on the adverse effects of anti\u2010epileptic drugs on fetal outcome, we evaluated our experience with prenatal diagnosis by ultrasonography and \u03b1\u2010 fetoprotein (AFP) determination in amniotic fluid. We compared these results with AFP values in maternal serum obtained prior to amniocentesis. From November 1985 to July 1990, amniocentesis at 16\u201318 weeks of gestation was performed in 267 pregnancies of 237 different women using anti\u2010epileptic drugs. Among 92 pregnancies with maternal valproic acid use, five (including one concordantly affected monozygotic twin\u2010pair) were terminated because of a spina bifida aperta, all prenatally diagnosed by AFP determination and acetylcholinesterase electrophoresis in amniotic fluid. The maternal serum AFP level was raised (\u2a7e 2.5 multiples of the median (MOM) for singleton pregnancies and \u2a7e 4.5 MOM for twin pregnancies) in only two of these five affected pregnancies. We emphasize that maternal serum AFP levels may be unreliable for prenatal screening for fetal neural tube defects in women taking valproate and recommend that amniocentesis and fetal ultrasound examination should be offered directly.<\/jats:p>","DOI":"10.1002\/pd.1970121107","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:11:39Z","timestamp":1172988699000},"page":"893-897","source":"Crossref","is-referenced-by-count":35,"title":["Prenatal diagnosis of spina bifida aperta after first\u2010trimester valproate exposure"],"prefix":"10.1002","volume":"12","author":[{"given":"Juliette G. C.","family":"Omtzigt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans J.","family":"Los","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana M.","family":"Hagenaars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva S.","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"Lindhout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"340","article-title":"Foetale echografie en neurale\u2010buisdefecten: morfologische diagnose zonder klinische zekerheid","volume":"135","author":"Beekhuis J. 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G. C.","year":"1992","journal-title":"Neurology"},{"key":"e_1_2_1_15_1","unstructured":"Rosa F.(1983).Pregnancy outcome with maternal carbamazepine exposure. Food and Drug Administration (Document No. 1983\u2013ADR No. 11)."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199103073241006"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970121107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970121107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T08:45:42Z","timestamp":1698050742000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970121107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1992,11]]}},"alternative-id":["10.1002\/pd.1970121107"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970121107","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11]]}}}