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At 23 weeks' gestation, moderate ascites was detected by detailed ultrasound scan and keratan sulphate was found in the amniotic fluid. The pregnancy was terminated by prostaglandin induction and the diagnosis of mucopolysaccharidosis type IV A was confirmed by demonstration of a deficiency of <jats:italic>N<\/jats:italic>\u2010acetylgalactosamine\u20106\u2010sulphate (GalNac\u20106\u2010S) sulphatase in cultured amniotic cells and in post\u2010mortem fibroblast cultures. The activities of \u03b2\u2010galactosidase and arylsulphatase A were normal, ruling out Morquio disease type B and multiple sulphatase deficiency. These results indicate that mucopolysaccharidosis IV A (a disease that predominantly affects the skeletal system) may produce ascites in the fetus to such an extent that it can be detected by ultrasound.<\/jats:p>","DOI":"10.1002\/pd.1970121207","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T05:59:41Z","timestamp":1172987981000},"page":"1019-1029","source":"Crossref","is-referenced-by-count":39,"title":["Fetal presentation of morquio disease type A"],"prefix":"10.1002","volume":"12","author":[{"given":"Michael","family":"Beck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiltrud","family":"Coerdt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Merz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian C.","family":"Sewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80523-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513818709161423"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(59)90119-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00445802"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1986.tb01262.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.149.2.6414044"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80997-X"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80441-X"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(78)90157-2"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198403000-00025"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/34.3.247"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140415"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1979.tb00851.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970110612"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197302012880502"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320220304"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320340313"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.10_Spec_No.1391"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.151.3.6718738"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(79)90090-1"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970020305"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80707-5"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1988.tb03421.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.29.2.111"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00427708"},{"key":"e_1_2_1_27_1","first-page":"779","article-title":"Histochemical studies in Wolman's disease: report of an autopsy case accompanied with a large amount of milky ascites","volume":"23","author":"Uno Y.","year":"1973","journal-title":"Acta Pathol. 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