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The AFP median was significantly increased in smokers in a dose\u2010response association; hCG decreased by 21 per cent and uE3 decreased by 3 per cent in smokers in a non\u2010dose\u2010related fashion. Regression functions for adjustment of serum levels for weight and smoking should be considered in risk estimation for Down syndrome in order to give a woman's individual risk more precisely.<\/jats:p>","DOI":"10.1002\/pd.1970130207","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:37:28Z","timestamp":1172990248000},"page":"123-130","source":"Crossref","is-referenced-by-count":43,"title":["Adjustment formulae for maternal serum alpha\u2010fetoprotein, human chorionic gonadotropin, and unconjugated oestriol to maternal weight and smoking"],"prefix":"10.1002","volume":"13","author":[{"given":"Iris","family":"Bartels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Hoppe\u2010Sievert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Bockel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Herold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"Caesar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970070904"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90305-B"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06601.x"},{"key":"e_1_2_1_5_1","first-page":"212","article-title":"The effect of smoking in pregnancy on maternal serum alpha\u2010fetoprotein, unconjugated oestriol, human chorionic gonadotropin, progesterone, and dehydro\u2010epiandrosterone sulphate levels","volume":"97","author":"Cuckle H. 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