{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:03:44Z","timestamp":1765713824039},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,12,5]],"date-time":"2005-12-05T00:00:00Z","timestamp":1133740800000},"content-version":"vor","delay-in-days":4631,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Second\u2010trimester unconjugated oestriol (UE3) levels were measured retrospectively in maternal serum from 78 chromosomally abnormal pregnancies and 390 matched controls using a radioimmunoassay kit (Amersham AMERLEX\u2010M) optimized for use in the second trimester. Reduced levels of UE3 were found in a group of 49 Down's syndrome pregnancies with a median UE3 level of 0\u00b779 multiples of the median (MOM) of the controls. Four trisomy 18 pregnancies had UE3 levels less than 0\u00b77 MOM. There was a highly significant level of correlation between alpha\u2010fetoprotein (AFP) and UE3 levels in the controls (<jats:italic>r<\/jats:italic> = 0\u00b725, <jats:italic>P<\/jats:italic> &lt;0\u00b701), the Down's syndrome pregnancies (<jats:italic>r<\/jats:italic> = 0\u00b744, <jats:italic>p<\/jats:italic> 0\u00b701), and the other chromosome abnormalities (<jats:italic>r<\/jats:italic> = 0\u00b761, <jats:italic>p<\/jats:italic>0\u00b701). When used as an additional marker to AFP and human chorionic gonadotrophin in screening for Down's syndrome, UE3 does not appear to add to the sensitivity of such screening.<\/jats:p>","DOI":"10.1002\/pd.1970130406","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:44:39Z","timestamp":1172990679000},"page":"271-280","source":"Crossref","is-referenced-by-count":36,"title":["Second\u2010trimester unconjugated oestriol levels in maternal serum from chromosomally abnormal pregnancies using an optimized assay"],"prefix":"10.1002","volume":"13","author":[{"given":"J. A.","family":"Crossley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Aitken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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