{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:03:33Z","timestamp":1765713813158},"reference-count":6,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":4556,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Free \u03b2\u2010HCG is a new analyte that has been suggested to be superior to total HCG when used in combination with alpha\u2010fetoprotein (AFP) for Down syndrome risk screening in early pregnancy. We have evaluated this claim on 21 samples collected from Down syndrome pregnancies and 180 samples from unaffected pregnancies. The detection rates for the combination of AFP with free \u03b2\u2010HCG or the combination of AFP with total HCG were identical (71 per cent) but the initial screen positive rate (equivalent to the false\u2010positive rate) was 7\u00b75 per cent for AFP+free \u03b2\u2010HCG screening compared with 3\u00b75 per cent for AFP+ total HCG screening. We conclude that the case for free \u03b2\u2010HCG is unproven and suggest that further data be collected before free \u03b2\u2010HCG becomes acceptable.<\/jats:p>","DOI":"10.1002\/pd.1970130617","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:49:10Z","timestamp":1172990950000},"page":"535-537","source":"Crossref","is-referenced-by-count":14,"title":["A comparison of total and free \u03b2\u2010HCG assays in Down syndrome screening"],"prefix":"10.1002","volume":"13","author":[{"given":"S.","family":"Stone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Henley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"Dawson A. Jones G. Matharu M. Reynolds T.(1992).Serum screening for Down syndrome: a joint report for the Welsh Office Confidential Report: February."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90700-H"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456329002700506"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/clinchem\/37.6.809","article-title":"Evaluation of an assay of the free beta subunit of choriogonadotropin and its potential value in screening for Down's syndrome","volume":"37","author":"Spencer K.","year":"1991","journal-title":"Clin. Chem."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456329202900319"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6653.883"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970130617","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970130617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T15:47:39Z","timestamp":1698248859000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970130617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,6]]}},"alternative-id":["10.1002\/pd.1970130617"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970130617","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6]]}}}