{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:55:24Z","timestamp":1757699724652},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":4464,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Information on maternal age and maternal serum alpha\u2010fetoprotein, unconjugated oestriol (uE<jats:sub>3<\/jats:sub>), and human chorionic gonadotrophin (hCG) levels was used to investigate retrospectively the effect of estimating Edward's syndrome risk in women having multi\u2010marker screening for Down's syndrome. The screened population comprised 15 pregnancies affected by Edward's syndrome, 15 with Down's syndrome and 5472 unaffected pregnancies. The use of all three markers to estimate Edward's syndrome risk would have led to the detection of 10\u201312 (67\u201380 per cent) cases with a false\u2010positive rate of 0.3\u20130.6 per cent depending on the risk cut\u2010off. A further case would have been detected as a result of screening for Down's syndrome alone. Similar results were obtained when the Edward's syndrome risk was based on uE<jats:sub>3<\/jats:sub> and hCG only. These data suggest that extending Down's syndrome screening to include Edward's syndrome risk will yield a high detection rate with only a small increase in the false\u2010positive rate.<\/jats:p>","DOI":"10.1002\/pd.1970130908","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:52:56Z","timestamp":1172991176000},"page":"843-850","source":"Crossref","is-referenced-by-count":38,"title":["Expanding multiple marker screening for Down's syndrome to include Edward'S syndrome"],"prefix":"10.1002","volume":"13","author":[{"given":"G.","family":"Barkai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Chaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Zer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Cuckle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"A225","article-title":"Maternal serum beta human chorionic gonadotrophin (MSHCG) combined with maternal serum alpha fetoprotein (MSAFP) appears superior for prenatal screening for Down syndrome (DS) than either test alone","volume":"43","author":"Arab H.","year":"1988","journal-title":"Am. 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