{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T05:10:27Z","timestamp":1698297027703},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2005,11,21]],"date-time":"2005-11-21T00:00:00Z","timestamp":1132531200000},"content-version":"vor","delay-in-days":4434,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Initial screening for the common \u03b2\u2010thalassaemia mutations with allele\u2010specific oligonucleo\u2010tide probes in an at\u2010risk family suggested non\u2010paternity. Subsequent DNA fingerprinting of the members proved otherwise. The mother had a codon 41\/42 frameshift mutation and the father's defect, determined by direct sequencing of PCR\u2010amplified \u03b2 gene, was a codon 43 nonsense mutation. In the affected children, the close proximity of these two defects resulted in the absence of a hybridization signal to the normal probe in that region and a wrong assumption of homozygosity for the codon 41\/42 mutation. The non\u2010reactivity of the father's amplified DNA to the codon 41\/42 thalassaemic probe accounted for the initial wrong conclusion of non\u2010paternity. Since prior screening for \u03b2\u2010thalassaemia mutations is done in all prenatal diagnosis programmes and concomitant inheritance of these two defects is relatively common in the Chinese, this \u2018artefact\u2019 of false non\u2010paternity is worth noting.<\/jats:p>","DOI":"10.1002\/pd.1970131012","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T06:44:02Z","timestamp":1172990642000},"page":"977-982","source":"Crossref","is-referenced-by-count":5,"title":["False non\u2010paternity in a family for prenatal diagnosis of \u03b2\u2010thalassaemia"],"prefix":"10.1002","volume":"13","author":[{"given":"Vivian","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. P. T.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Todd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. K.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113632"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1182\/blood.V73.2.372.bloodjournal732372","article-title":"Rapid prenatal diagnosis of \u03b2 thalassemia using DNA amplification and nonradioactive probes","volume":"73","author":"Cai S.\u2010P.","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_4_1","first-page":"678","article-title":"Distribution of \u03b2\u2010thalassemia mutations in South China and their association with haplotype","volume":"41","author":"Chan V.","year":"1987","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830250407"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1182\/blood.V72.4.1420.1420","article-title":"A novel \u03b2\u2010thalassaemia frameshift mutation (codon 14\/15), detectable by direct visualization of abnormal restriction fragment in amplified genomic DNA","volume":"72","author":"Chan V.","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91892-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1182\/blood.V74.2.852.852","article-title":"Characterization of a spontaneous mutation in \u03b2\u2010thalassaemia associated with advanced paternal age","volume":"74","author":"Chehab F. F.","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.1.278"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/314067a0"},{"key":"e_1_2_1_11_1","first-page":"1","volume-title":"Perinatal Hematology","author":"Rodeck C. H.","year":"1989"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198809013190903"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.1970131012","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.1970131012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T14:54:51Z","timestamp":1698245691000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.1970131012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1993,10]]}},"alternative-id":["10.1002\/pd.1970131012"],"URL":"https:\/\/doi.org\/10.1002\/pd.1970131012","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10]]}}}